A0A167W3X4 protein (Fibularhizoctonia sp. CBS109695)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A167W3X4

Uncharacterized protein. (309 aa)

Predicted Functional Partners:

A0A166F9S7

0.914

A0A167VPF9

0.913

A0A166G5H9

0.904

A0A166JDF8

0.899

A0A166SXC5

0.892

A0A166FIN6

0.891

A0A167US63

0.881

A0A166J9U7

0.868

A0A166R4B9

0.867

A0A166E1I6

0.866

Your Current Organism:

Fibularhizoctonia sp. CBS109695

NCBI taxonomy Id: 436010
Other names: F. sp. CBS 109695, Fibularhizoctonia sp. CBS 109695, Fibulorhizoctonia sp. CBS 109695

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A166E1I6	A0A166F9S7	Diphenol oxidase-A2.	26S proteasome regulatory complex ATPase RPT4; Belongs to the AAA ATPase family.	0.999
A0A166E1I6	A0A166FIN6	Diphenol oxidase-A2.	Uncharacterized protein.	0.999
A0A166E1I6	A0A166G5H9	Diphenol oxidase-A2.	26S proteasome regulatory complex ATPase RPT6; Belongs to the AAA ATPase family.	0.999
A0A166E1I6	A0A166J9U7	Diphenol oxidase-A2.	PCI-domain-containing protein.	0.999
A0A166E1I6	A0A166JDF8	Diphenol oxidase-A2.	26S proteasome subunit P45; Belongs to the AAA ATPase family.	0.999
A0A166E1I6	A0A166R4B9	Diphenol oxidase-A2.	PCI domain-containing protein.	0.999
A0A166E1I6	A0A166SXC5	Diphenol oxidase-A2.	26S proteasome subunit P45; Belongs to the AAA ATPase family.	0.999
A0A166E1I6	A0A167US63	Diphenol oxidase-A2.	PCI-domain-containing protein.	0.999
A0A166E1I6	A0A167VPF9	Diphenol oxidase-A2.	26S proteasome subunit P45; Belongs to the AAA ATPase family.	0.999
A0A166E1I6	A0A167W3X4	Diphenol oxidase-A2.	Uncharacterized protein.	0.866
A0A166F9S7	A0A166E1I6	26S proteasome regulatory complex ATPase RPT4; Belongs to the AAA ATPase family.	Diphenol oxidase-A2.	0.999
A0A166F9S7	A0A166FIN6	26S proteasome regulatory complex ATPase RPT4; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.999
A0A166F9S7	A0A166G5H9	26S proteasome regulatory complex ATPase RPT4; Belongs to the AAA ATPase family.	26S proteasome regulatory complex ATPase RPT6; Belongs to the AAA ATPase family.	0.999
A0A166F9S7	A0A166J9U7	26S proteasome regulatory complex ATPase RPT4; Belongs to the AAA ATPase family.	PCI-domain-containing protein.	0.999
A0A166F9S7	A0A166JDF8	26S proteasome regulatory complex ATPase RPT4; Belongs to the AAA ATPase family.	26S proteasome subunit P45; Belongs to the AAA ATPase family.	0.999
A0A166F9S7	A0A166R4B9	26S proteasome regulatory complex ATPase RPT4; Belongs to the AAA ATPase family.	PCI domain-containing protein.	0.998
A0A166F9S7	A0A166SXC5	26S proteasome regulatory complex ATPase RPT4; Belongs to the AAA ATPase family.	26S proteasome subunit P45; Belongs to the AAA ATPase family.	0.999
A0A166F9S7	A0A167US63	26S proteasome regulatory complex ATPase RPT4; Belongs to the AAA ATPase family.	PCI-domain-containing protein.	0.999
A0A166F9S7	A0A167VPF9	26S proteasome regulatory complex ATPase RPT4; Belongs to the AAA ATPase family.	26S proteasome subunit P45; Belongs to the AAA ATPase family.	0.999
A0A166F9S7	A0A167W3X4	26S proteasome regulatory complex ATPase RPT4; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.914

page 1 of 6

Network Stats

number of nodes:

5

number of edges:

5

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

4

PPI enrichment p-value:

0.373

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

11 of 163

2.15

7.56

1.66e-20

GO:0000245

Spliceosomal complex assembly

3 of 22

2.45

2.33

4.10e-05

GO:0022618

Ribonucleoprotein complex assembly

4 of 118

1.85

2.0

5.10e-05

GO:0000393

Spliceosomal conformational changes to generate catalytic conformation

2 of 6

2.84

1.63

0.0011

GO:0033120

Positive regulation of RNA splicing

2 of 13

2.51

1.31

0.0039

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

6 of 801

1.19

1.0

0.0014

GO:0003676

Nucleic acid binding

7 of 2023

0.86

0.59

0.0095

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000974

Prp19 complex

7 of 10

3.16

9.4

3.14e-18

GO:0071013

Catalytic step 2 spliceosome

9 of 70

2.43

8.21

1.13e-18

GO:0005681

Spliceosomal complex

11 of 160

2.16

7.8

2.77e-21

GO:0071007

U2-type catalytic step 2 spliceosome

6 of 12

3.02

7.57

6.86e-15

GO:0071014

post-mRNA release spliceosomal complex

4 of 9

2.97

4.69

2.21e-09

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9007

Mixed, incl. post-mRNA release spliceosomal complex, and Catalytic step 1 spliceosome

9 of 26

2.86

10.79

6.37e-22

CL:9040

Prp19 complex, and AAA domain

7 of 7

3.32

9.95

4.53e-19

CL:8855

Spliceosomal complex

11 of 119

2.29

8.79

2.99e-22

CL:9013

Mixed, incl. Catalytic step 1 spliceosome, and Domain in DAP-5, eIF4G, MA-3 and other proteins.

2 of 6

2.84

1.57

0.0014

CL:8966

Prp19 complex

2 of 6

2.84

1.57

0.0014

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

11 of 184

2.1

7.48

1.94e-21

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72163

mRNA Splicing - Major Pathway

11 of 209

2.04

6.81

6.15e-20

MAP-72172

mRNA Splicing

11 of 220

2.02

6.68

6.15e-20

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 297

1.89

5.7

8.93e-19

MAP-8953854

Metabolism of RNA

11 of 729

1.5

3.17

1.15e-14

MAP-6781823

Formation of TC-NER Pre-Incision Complex

4 of 71

2.07

2.48

8.59e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000974

Prp19 complex

7 of 10

3.16

9.14

1.00e-17

GOCC:0005681

Spliceosomal complex

9 of 90

2.32

7.49

1.01e-17

GOCC:0071013

Catalytic step 2 spliceosome

6 of 22

2.75

6.52

2.96e-13

GOCC:0071007

U2-type catalytic step 2 spliceosome

4 of 7

3.08

4.75

1.95e-09

GOCC:0032991

Protein-containing complex

11 of 2601

0.95

1.13

7.04e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045075

Pre-mRNA-splicing factor Syf1-like

2 of 3

3.14

1.15

0.0085

IPR003107

HAT (Half-A-TPR) repeat

2 of 11

2.58

0.81

0.0333

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00386

HAT (Half-A-TPR) repeats

2 of 11

2.58

1.14

0.0085

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