STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (311 aa)    
Predicted Functional Partners:
Nmar_0493
PFAM: Uroporphyrinogen III synthase HEM4; KEGG: sat:SYN_02272 uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase.
 
 0.999
Nmar_0492
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: neu:NE0532 uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family.
  
 0.998
Nmar_0509
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: bld:BLi02943 delta-aminolevulinic acid dehydratase; RBL00019; Belongs to the ALAD family.
 
 0.995
hemA-2
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.983
hemL
TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: mja:MJ0603 glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
  
 0.967
Nmar_0059
KEGG: mja:MJ1578 precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase.
    
 0.921
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.850
Nmar_1017
PFAM: aminotransferase class-III; KEGG: hbu:Hbut_1430 glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.718
Nmar_0488
PFAM: low molecular weight phosphotyrosine protein phosphatase; KEGG: cef:CE0877 putative arsenate reductase.
  
    0.709
Nmar_0489
PFAM: major intrinsic protein; KEGG: bca:BCE_A0165 MIP family channel protein.
  
    0.702
Your Current Organism:
Nitrosopumilus maritimus
NCBI taxonomy Id: 436308
Other names: N. maritimus SCM1, Nitrosopumilus maritimus SCM1, Nitrosopumilus maritimus str. SCM1, Nitrosopumilus maritimus strain SCM1, Seattle Aquarium strain SCM1
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