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ilvC protein (Nitrosopumilus maritimus) - STRING interaction network
"ilvC" - Ketol-acid reductoisomerase in Nitrosopumilus maritimus
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ilvCKetol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate; Belongs to the ketol-acid reductoisomerase family (332 aa)    
Predicted Functional Partners:
ilvD
KEGG- sto-ST2172 dihydroxy-acid dehydratase; TIGRFAM- dihydroxy-acid dehydratase; PFAM- dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family (558 aa)
 
  0.995
Nmar_1072
TIGRFAM- acetolactate synthase, large subunit, biosynthetic type; PFAM- thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG- pfu-PF0935 acetolactate synthase large subunit (566 aa)
 
 
  0.991
Nmar_1071
TIGRFAM- acetolactate synthase, small subunit; PFAM- amino acid-binding ACT domain protein; KEGG- mja-MJ0161 acetolactate synthase small subunit (161 aa)
 
  0.990
Nmar_0546
Aminotransferase; PFAM- Chorismate mutase; aminotransferase class I and II; KEGG- tpt-Tpet_1516 aminotransferase, class I and II (456 aa)
   
   
  0.880
Nmar_1267
PFAM- dihydropteroate synthase DHPS; Methionine synthase B12-binding module cap domain protein; Vitamin B12 dependent methionine synthase activation region; cobalamin B12-binding domain protein; KEGG- rrs-RoseRS_0064 methionine synthase (832 aa)
   
   
  0.813
Nmar_1559
KEGG- mtp-Mthe_0080 ATP phosphoribosyltransferase; TIGRFAM- ATP phosphoribosyltransferase; PFAM- Histidine biosynthesis protein HisG domain; ATP phosphoribosyltransferase catalytic region (325 aa)
   
   
  0.681
Nmar_0848
TIGRFAM- threonine dehydratase; PFAM- Pyridoxal-5’-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; KEGG- chy-CHY_2459 threonine dehydratase (402 aa)
 
 
  0.649
lysZ
Putative [LysW]-aminoadipate/[LysW]-glutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily (267 aa)
 
   
  0.649
Nmar_1008
D-alanine--D-alanine ligase; PFAM- peptidase M20; protein of unknown function DUF201; D-alanine--D-alanine ligase domain protein; RimK domain protein ATP-grasp; KEGG- amt-Amet_3744 D-alanine--D-alanine ligase domain protein (743 aa)
   
 
  0.646
Nmar_0964
KEGG- sto-ST0342 adenosylhomocysteinase; TIGRFAM- adenosylhomocysteinase; PFAM- S-adenosyl-L-homocysteine hydrolase; S-adenosyl-L-homocysteine hydrolase, NAD binding (413 aa)
   
   
  0.628
Your Current Organism:
Nitrosopumilus maritimus
NCBI taxonomy Id: 436308
Other names: N. maritimus SCM1, Nitrosopumilus maritimus, Nitrosopumilus maritimus SCM1, Nitrosopumilus maritimus str. SCM1, Nitrosopumilus maritimus strain SCM1, Seattle Aquarium strain SCM1
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