STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Nmar_1632PFAM: DNA topoisomerase type IA zn finger domain protein; KEGG: tvo:TVN0019 DNA topoisomerase I. (152 aa)    
Predicted Functional Partners:
Nmar_1245
PFAM: SMC domain protein; KEGG: sto:ST2108 hypothetical purine NTPase.
  
 0.865
Nmar_0437
ERCC4 domain protein; PFAM: helix-hairpin-helix motif; ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding class 1; KEGG: pho:PH1896m ERCC4-like helicase/ERCC4-type nuclease.
    
 0.816
Nmar_0471
KEGG: cth:Cthe_2109 copper amine oxidase-like protein.
    
 0.816
fen
XPG I domain protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...]
  
 0.722
Nmar_0428
PFAM: RNA polymerase dimerisation; RNA polymerase insert; SMART: RNA polymerase RpoA/D/Rpb3-type; KEGG: mst:Msp_0868 RpoD.
   
 
 0.713
rpoA2
DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.691
Nmar_1213
PFAM: SMC domain protein; KEGG: mth:MTH540 intracellular protein transport protein.
  
 0.682
pcn
Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
   
 0.670
leuS
TIGRFAM: leucyl-tRNA synthetase; KEGG: mba:Mbar_A2048 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.641
Nmar_1630
PFAM: protein of unknown function DUF35; KEGG: sai:Saci_2291 conserved archaeal protein.
  
    0.610
Your Current Organism:
Nitrosopumilus maritimus
NCBI taxonomy Id: 436308
Other names: N. maritimus SCM1, Nitrosopumilus maritimus SCM1, Nitrosopumilus maritimus str. SCM1, Nitrosopumilus maritimus strain SCM1, Seattle Aquarium strain SCM1
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