STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Nmar_1708PFAM: heat shock protein Hsp20; KEGG: mse:Msed_1294 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (126 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein DnaK; Acts as a chaperone.
  
 
 0.642
Nmar_0095
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
  
 0.531
Nmar_1024
PFAM: heat shock protein DnaJ domain protein; KEGG: cfa:609460 DnaJ (Hsp40) homolog, subfamily B, member 8.
  
 
 0.504
Nmar_1706
PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: aae:aq_1910 hypothetical protein.
  
    0.452
Nmar_0831
Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating); PFAM: glyceraldehyde 3-phosphate dehydrogenase; KEGG: hal:VNG0095G glyceraldehyde 3-phosphate dehydrogenase.
 
 
 0.451
pyrH
Uridylate kinase, putative; Catalyzes the reversible phosphorylation of UMP to UDP.
       0.427
tmk
PFAM: thymidylate kinase; KEGG: ehi:55.t00018 thymidylate kinase, putative.
       0.423
Your Current Organism:
Nitrosopumilus maritimus
NCBI taxonomy Id: 436308
Other names: N. maritimus SCM1, Nitrosopumilus maritimus SCM1, Nitrosopumilus maritimus str. SCM1, Nitrosopumilus maritimus strain SCM1, Seattle Aquarium strain SCM1
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