LOC109973423 protein (Monopterus albus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

LOC109973423

Major facilitator superfamily domain containing 4Aa. (493 aa)

Predicted Functional Partners:

ENSMALP00000026776

0.489

slf1

0.424

arid4b

0.418

arid4a

0.418

wdr90

0.407

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMALP00000026776	LOC109973423	ENSMALP00000026776	ENSMALP00000000431	CUB and zona pellucida-like domains 1, tandem duplicate 1.	Major facilitator superfamily domain containing 4Aa.	0.489
LOC109973423	ENSMALP00000026776	ENSMALP00000000431	ENSMALP00000026776	Major facilitator superfamily domain containing 4Aa.	CUB and zona pellucida-like domains 1, tandem duplicate 1.	0.489
LOC109973423	arid4a	ENSMALP00000000431	ENSMALP00000027624	Major facilitator superfamily domain containing 4Aa.	AT rich interactive domain 4A (RBP1-like).	0.418
LOC109973423	arid4b	ENSMALP00000000431	ENSMALP00000007319	Major facilitator superfamily domain containing 4Aa.	Translocase of outer mitochondrial membrane 20.	0.418
LOC109973423	slf1	ENSMALP00000000431	ENSMALP00000012001	Major facilitator superfamily domain containing 4Aa.	SMC5-SMC6 complex localization factor 1.	0.424
LOC109973423	wdr90	ENSMALP00000000431	ENSMALP00000002133	Major facilitator superfamily domain containing 4Aa.	WD repeat domain 90.	0.407
arid4a	LOC109973423	ENSMALP00000027624	ENSMALP00000000431	AT rich interactive domain 4A (RBP1-like).	Major facilitator superfamily domain containing 4Aa.	0.418
arid4a	arid4b	ENSMALP00000027624	ENSMALP00000007319	AT rich interactive domain 4A (RBP1-like).	Translocase of outer mitochondrial membrane 20.	0.635
arid4b	LOC109973423	ENSMALP00000007319	ENSMALP00000000431	Translocase of outer mitochondrial membrane 20.	Major facilitator superfamily domain containing 4Aa.	0.418
arid4b	arid4a	ENSMALP00000007319	ENSMALP00000027624	Translocase of outer mitochondrial membrane 20.	AT rich interactive domain 4A (RBP1-like).	0.635
slf1	LOC109973423	ENSMALP00000012001	ENSMALP00000000431	SMC5-SMC6 complex localization factor 1.	Major facilitator superfamily domain containing 4Aa.	0.424
wdr90	LOC109973423	ENSMALP00000002133	ENSMALP00000000431	WD repeat domain 90.	Major facilitator superfamily domain containing 4Aa.	0.407

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.938

expected number of edges:

30

PPI enrichment p-value:

0.0156

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006091

Generation of precursor metabolites and energy

6 of 172

1.43

1.65

2.47e-05

GO:0006096

Glycolytic process

3 of 20

2.06

1.58

0.00085

GO:0006213

Pyrimidine nucleoside metabolic process

2 of 4

2.59

1.52

0.0016

GO:1901135

Carbohydrate derivative metabolic process

8 of 410

1.18

1.36

6.98e-06

GO:0055086

Nucleobase-containing small molecule metabolic process

6 of 233

1.3

1.35

9.57e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016620

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

3 of 27

1.93

1.15

0.0058

GO:0016744

Transketolase or transaldolase activity

2 of 7

2.34

0.97

0.0164

GO:0016832

Aldehyde-lyase activity

2 of 13

2.07

0.78

0.0358

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

5 of 574

0.83

0.47

0.0384

GO:0005737

Cytoplasm

9 of 2295

0.48

0.31

0.0384

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:21110849

(2010) Differential proteomic analysis highlights metabolic strategies associated with balhimycin production in Amycolatopsis balhimycina chemostat cultivations.

2 of 18

1.93

0.91

0.0183

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3856

Glycolysis, and Transketolase or transaldolase activity

5 of 15

2.41

4.01

1.24e-08

CL:3847

Mixed, incl. Glycolysis / Gluconeogenesis, and NADPH regeneration

7 of 85

1.8

3.18

8.47e-09

CL:3858

Glycolysis

3 of 10

2.36

2.14

8.85e-05

CL:3860

Glycolysis

2 of 5

2.49

1.23

0.0056

CL:1351

5-Nucleotidase/apyrase, and Pyrimidine nucleoside metabolic process

2 of 6

2.41

1.18

0.0068

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00030

Pentose phosphate pathway

5 of 82

1.67

2.13

6.41e-06

map00010

Glycolysis / Gluconeogenesis

4 of 105

1.47

1.33

0.00056

map01200

Carbon metabolism

5 of 240

1.21

1.09

0.00056

map01230

Biosynthesis of amino acids

4 of 257

1.08

0.76

0.0070

map01120

Microbial metabolism in diverse environments

6 of 829

0.75

0.53

0.0070

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-168249

Innate Immune System

3 of 61

1.58

1.21

0.0021

MAP-168256

Immune System

3 of 72

1.51

1.17

0.0021

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0704

Schiff base

2 of 7

2.34

1.03

0.0126

KW-0324

Glycolysis

2 of 10

2.19

1.02

0.0126

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