mrpl19 protein (Monopterus albus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

mrpl19

Mitochondrial ribosomal protein L19. (290 aa)

Predicted Functional Partners:

Rps15

0.999

mrpl12

0.999

mrps6

0.999

ENSMALP00000003978

0.999

rps11

0.999

Rpl35

0.999

mrps12

0.999

mrpl32

0.999

mrpl33

0.999

rps18

0.999

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMALP00000003978	Rpl35	ENSMALP00000003978	ENSMALP00000005673	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Ribosomal protein L35.	0.999
ENSMALP00000003978	Rps15	ENSMALP00000003978	ENSMALP00000000891	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.999
ENSMALP00000003978	mrpl12	ENSMALP00000003978	ENSMALP00000001849	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial ribosomal protein L12.	0.999
ENSMALP00000003978	mrpl19	ENSMALP00000003978	ENSMALP00000000778	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial ribosomal protein L19.	0.999
ENSMALP00000003978	mrpl32	ENSMALP00000003978	ENSMALP00000005869	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial ribosomal protein L32.	0.999
ENSMALP00000003978	mrpl33	ENSMALP00000003978	ENSMALP00000006592	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial ribosomal protein L33.	0.999
ENSMALP00000003978	mrps12	ENSMALP00000003978	ENSMALP00000005846	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial ribosomal protein S12; Belongs to the universal ribosomal protein uS12 family.	0.999
ENSMALP00000003978	mrps6	ENSMALP00000003978	ENSMALP00000003456	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial ribosomal protein S6.	0.999
ENSMALP00000003978	rps11	ENSMALP00000003978	ENSMALP00000005611	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.	0.999
ENSMALP00000003978	rps18	ENSMALP00000003978	ENSMALP00000008342	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Ribosomal protein S18.	0.999
Rpl35	ENSMALP00000003978	ENSMALP00000005673	ENSMALP00000003978	Ribosomal protein L35.	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	0.999
Rpl35	Rps15	ENSMALP00000005673	ENSMALP00000000891	Ribosomal protein L35.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.999
Rpl35	mrpl12	ENSMALP00000005673	ENSMALP00000001849	Ribosomal protein L35.	Mitochondrial ribosomal protein L12.	0.999
Rpl35	mrpl19	ENSMALP00000005673	ENSMALP00000000778	Ribosomal protein L35.	Mitochondrial ribosomal protein L19.	0.999
Rpl35	mrpl32	ENSMALP00000005673	ENSMALP00000005869	Ribosomal protein L35.	Mitochondrial ribosomal protein L32.	0.999
Rpl35	mrpl33	ENSMALP00000005673	ENSMALP00000006592	Ribosomal protein L35.	Mitochondrial ribosomal protein L33.	0.999
Rpl35	mrps12	ENSMALP00000005673	ENSMALP00000005846	Ribosomal protein L35.	Mitochondrial ribosomal protein S12; Belongs to the universal ribosomal protein uS12 family.	0.988
Rpl35	mrps6	ENSMALP00000005673	ENSMALP00000003456	Ribosomal protein L35.	Mitochondrial ribosomal protein S6.	0.999
Rpl35	rps11	ENSMALP00000005673	ENSMALP00000005611	Ribosomal protein L35.	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.	0.999
Rpl35	rps18	ENSMALP00000005673	ENSMALP00000008342	Ribosomal protein L35.	Ribosomal protein S18.	0.999

page 1 of 6

Network Stats

number of nodes:

7

number of edges:

11

average node degree:

3.14

avg. local clustering coefficient:

0.857

expected number of edges:

6

PPI enrichment p-value:

0.0474

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018345

Protein palmitoylation

5 of 35

2.41

3.53

1.32e-07

GO:0018230

peptidyl-L-cysteine S-palmitoylation

4 of 24

2.48

2.81

4.59e-06

GO:0070200

Establishment of protein localization to telomere

2 of 5

2.86

1.29

0.0046

GO:0032202

Telomere assembly

2 of 5

2.86

1.29

0.0046

GO:0061820

Telomeric D-loop disassembly

2 of 7

2.71

1.23

0.0058

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019706

Protein-cysteine S-palmitoyltransferase activity

3 of 29

2.27

1.45

0.0019

GO:0062037

D-loop DNA binding

2 of 5

2.86

1.36

0.0035

GO:0032357

Oxidized purine DNA binding

2 of 11

2.51

1.07

0.0110

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070187

Shelterin complex

2 of 7

2.71

1.0

0.0155

GO:0002178

Palmitoyltransferase complex

2 of 11

2.51

0.99

0.0155

GO:0000781

Chromosome, telomeric region

3 of 104

1.71

0.91

0.0155

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20205

peptidyl-L-cysteine S-palmitoylation, and Regulation of protein localization to phagocytic vesicle

5 of 12

2.87

5.0

4.84e-10

CL:20206

DHHC palmitoyltransferase

3 of 6

2.95

2.8

7.63e-06

CL:13601

Shelterin complex

2 of 5

2.86

1.35

0.0036

CL:20217

Mixed, incl. Golgin subfamily A member 7/ERF4 family, and Regulation of protein localization to phagocytic vesicle

2 of 6

2.78

1.31

0.0042

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-174437

Removal of the Flap Intermediate from the C-strand

3 of 18

2.48

1.9

0.00029

MAP-174414

Processive synthesis on the C-strand of the telomere

3 of 20

2.43

1.89

0.00029

MAP-174417

Telomere C-strand (Lagging Strand) Synthesis

3 of 37

2.16

1.64

0.00071

MAP-180786

Extension of Telomeres

3 of 64

1.92

1.31

0.0026

MAP-174430

Telomere C-strand synthesis initiation

2 of 14

2.41

1.1

0.0095

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0002178

Palmitoyltransferase complex

2 of 10

2.55

0.81

0.0334

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0012

Acyltransferase

3 of 69

1.89

1.3

0.0026

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01529

DHHC palmitoyltransferase

3 of 23

2.37

1.67

0.00075

PF10256

Golgin subfamily A member 7/ERF4 family

2 of 4

2.95

1.28

0.0048

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001594

Palmitoyltransferase, DHHC domain

3 of 23

2.37

1.42

0.0023

IPR019383

Golgin subfamily A member 7/ERF4

2 of 4

2.95

1.01

0.0148

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About