SV2A protein (Monopterus albus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

SV2A

Synaptic vesicle glycoprotein 2A. (737 aa)

Predicted Functional Partners:

LAMC2

0.687

lamc1

0.687

LOC109971320

0.687

lamb3

0.686

lama4

0.671

lamb2

0.668

LOC109952782

0.668

ENSMALP00000019405

0.661

ENSMALP00000018960

0.650

ints1

0.540

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMALP00000018960	ENSMALP00000019405	ENSMALP00000018960	ENSMALP00000019405	Uncharacterized protein.	Uncharacterized protein.	0.512
ENSMALP00000018960	LAMC2	ENSMALP00000018960	ENSMALP00000000313	Uncharacterized protein.	Laminin subunit gamma 2.	0.468
ENSMALP00000018960	LOC109952782	ENSMALP00000018960	ENSMALP00000024882	Uncharacterized protein.	Laminin, beta 1a.	0.587
ENSMALP00000018960	LOC109971320	ENSMALP00000018960	ENSMALP00000016619	Uncharacterized protein.	Laminin, gamma 3.	0.468
ENSMALP00000018960	SV2A	ENSMALP00000018960	ENSMALP00000008740	Uncharacterized protein.	Synaptic vesicle glycoprotein 2A.	0.650
ENSMALP00000018960	lamb2	ENSMALP00000018960	ENSMALP00000023664	Uncharacterized protein.	Laminin, beta 2 (laminin S).	0.587
ENSMALP00000018960	lamb3	ENSMALP00000018960	ENSMALP00000022641	Uncharacterized protein.	Uncharacterized protein.	0.450
ENSMALP00000018960	lamc1	ENSMALP00000018960	ENSMALP00000000674	Uncharacterized protein.	Laminin, gamma 1.	0.468
ENSMALP00000019405	ENSMALP00000018960	ENSMALP00000019405	ENSMALP00000018960	Uncharacterized protein.	Uncharacterized protein.	0.512
ENSMALP00000019405	LAMC2	ENSMALP00000019405	ENSMALP00000000313	Uncharacterized protein.	Laminin subunit gamma 2.	0.838
ENSMALP00000019405	LOC109971320	ENSMALP00000019405	ENSMALP00000016619	Uncharacterized protein.	Laminin, gamma 3.	0.838
ENSMALP00000019405	SV2A	ENSMALP00000019405	ENSMALP00000008740	Uncharacterized protein.	Synaptic vesicle glycoprotein 2A.	0.661
ENSMALP00000019405	lama4	ENSMALP00000019405	ENSMALP00000007075	Uncharacterized protein.	Laminin, alpha 4.	0.712
ENSMALP00000019405	lamc1	ENSMALP00000019405	ENSMALP00000000674	Uncharacterized protein.	Laminin, gamma 1.	0.838
LAMC2	ENSMALP00000018960	ENSMALP00000000313	ENSMALP00000018960	Laminin subunit gamma 2.	Uncharacterized protein.	0.468
LAMC2	ENSMALP00000019405	ENSMALP00000000313	ENSMALP00000019405	Laminin subunit gamma 2.	Uncharacterized protein.	0.838
LAMC2	LOC109952782	ENSMALP00000000313	ENSMALP00000024882	Laminin subunit gamma 2.	Laminin, beta 1a.	0.856
LAMC2	SV2A	ENSMALP00000000313	ENSMALP00000008740	Laminin subunit gamma 2.	Synaptic vesicle glycoprotein 2A.	0.687
LAMC2	lama4	ENSMALP00000000313	ENSMALP00000007075	Laminin subunit gamma 2.	Laminin, alpha 4.	0.780
LAMC2	lamb2	ENSMALP00000000313	ENSMALP00000023664	Laminin subunit gamma 2.	Laminin, beta 2 (laminin S).	0.856

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.895

expected number of edges:

13

PPI enrichment p-value:

0.085

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006006

Glucose metabolic process

3 of 10

1.96

1.4

0.0017

GO:0005996

Monosaccharide metabolic process

4 of 29

1.62

1.3

0.0014

GO:0006090

Pyruvate metabolic process

3 of 15

1.78

1.18

0.0040

GO:0006091

Generation of precursor metabolites and energy

5 of 77

1.29

1.08

0.0014

GO:0006098

Pentose-phosphate shunt

2 of 3

2.3

1.06

0.0111

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

3 of 12

1.88

1.09

0.0073

GO:0016903

Oxidoreductase activity, acting on the aldehyde or oxo group of donors

3 of 22

1.61

0.93

0.0121

GO:0016853

Isomerase activity

4 of 75

1.21

0.76

0.0131

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:622

Pentose phosphate pathway, and Glyceraldehyde-3-phosphate dehydrogenase, type I

8 of 20

2.08

5.04

1.05e-12

CL:649

Pentose phosphate pathway

4 of 6

2.3

2.94

1.73e-06

CL:426

Mixed, incl. Carbon metabolism, and Fatty acid metabolism

11 of 148

1.35

2.43

1.05e-12

CL:623

Glycolysis, and Glyceraldehyde-3-phosphate dehydrogenase, type I

4 of 13

1.97

2.28

1.66e-05

CL:626

Glycolysis

2 of 6

2.0

0.84

0.0264

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00030

Pentose phosphate pathway

7 of 22

1.98

4.31

3.12e-11

map01200

Carbon metabolism

11 of 86

1.59

3.68

8.75e-16

map00010

Glycolysis / Gluconeogenesis

5 of 42

1.55

2.02

3.91e-06

map01230

Biosynthesis of amino acids

8 of 130

1.27

1.81

2.55e-08

map01120

Microbial metabolism in diverse environments

11 of 248

1.13

1.64

3.12e-11

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0312

Gluconeogenesis

2 of 4

2.18

0.99

0.0145

KW-0413

Isomerase

4 of 59

1.31

0.9

0.0069

KW-0324

Glycolysis

2 of 9

1.83

0.76

0.0352

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17147

Pyruvate:ferredoxin oxidoreductase core domain II

2 of 2

2.48

0.84

0.0300

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

4 of 11

2.04

1.98

0.00011

IPR009014

Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II

3 of 7

2.11

1.41

0.0020

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

2 of 6

2.0

0.82

0.0281

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