azin1 protein (Monopterus albus) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

azin1

Antizyme inhibitor 1a; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (451 aa)

Predicted Functional Partners:

oaz1

0.913

LOC109970787

0.913

ENSMALP00000022613

0.879

aass

0.783

srm

0.781

agmat

0.750

sms

0.747

ALDH18A1

0.733

oat

0.709

LOC109969653

0.705

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH18A1	LOC109969653	ENSMALP00000009374	ENSMALP00000018691	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Arginase.	0.714
ALDH18A1	aass	ENSMALP00000009374	ENSMALP00000021562	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Aminoadipate-semialdehyde synthase.	0.718
ALDH18A1	agmat	ENSMALP00000009374	ENSMALP00000002432	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Agmatine ureohydrolase (agmatinase); Belongs to the arginase family.	0.714
ALDH18A1	azin1	ENSMALP00000009374	ENSMALP00000011175	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Antizyme inhibitor 1a; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.733
ALDH18A1	oat	ENSMALP00000009374	ENSMALP00000003799	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.997
ALDH18A1	sms	ENSMALP00000009374	ENSMALP00000020974	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Spermine synthase.	0.718
ALDH18A1	srm	ENSMALP00000009374	ENSMALP00000030825	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Spermidine synthase; Belongs to the spermidine/spermine synthase family.	0.718
ENSMALP00000022613	azin1	ENSMALP00000022613	ENSMALP00000011175	Ornithine decarboxylase antizyme 2a.	Antizyme inhibitor 1a; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.879
ENSMALP00000022613	sms	ENSMALP00000022613	ENSMALP00000020974	Ornithine decarboxylase antizyme 2a.	Spermine synthase.	0.502
LOC109969653	ALDH18A1	ENSMALP00000018691	ENSMALP00000009374	Arginase.	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	0.714
LOC109969653	agmat	ENSMALP00000018691	ENSMALP00000002432	Arginase.	Agmatine ureohydrolase (agmatinase); Belongs to the arginase family.	0.477
LOC109969653	azin1	ENSMALP00000018691	ENSMALP00000011175	Arginase.	Antizyme inhibitor 1a; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.705
LOC109969653	oat	ENSMALP00000018691	ENSMALP00000003799	Arginase.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.998
LOC109969653	sms	ENSMALP00000018691	ENSMALP00000020974	Arginase.	Spermine synthase.	0.814
LOC109969653	srm	ENSMALP00000018691	ENSMALP00000030825	Arginase.	Spermidine synthase; Belongs to the spermidine/spermine synthase family.	0.864
LOC109970787	azin1	ENSMALP00000018683	ENSMALP00000011175	Ornithine decarboxylase antizyme 1b.	Antizyme inhibitor 1a; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.913
aass	ALDH18A1	ENSMALP00000021562	ENSMALP00000009374	Aminoadipate-semialdehyde synthase.	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	0.718
aass	azin1	ENSMALP00000021562	ENSMALP00000011175	Aminoadipate-semialdehyde synthase.	Antizyme inhibitor 1a; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.783
aass	oat	ENSMALP00000021562	ENSMALP00000003799	Aminoadipate-semialdehyde synthase.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.716
aass	srm	ENSMALP00000021562	ENSMALP00000030825	Aminoadipate-semialdehyde synthase.	Spermidine synthase; Belongs to the spermidine/spermine synthase family.	0.933

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.833

expected number of edges:

10

PPI enrichment p-value:

0.000135

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060393

Regulation of pathway-restricted SMAD protein phosphorylation

9 of 62

2.45

8.0

6.33e-18

GO:0010862

Positive regulation of pathway-restricted SMAD protein phosphorylation

8 of 50

2.49

7.33

5.80e-16

GO:0090100

Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

9 of 89

2.29

7.07

8.89e-17

GO:0060395

SMAD protein signal transduction

8 of 62

2.4

6.86

2.28e-15

GO:0030509

BMP signaling pathway

8 of 71

2.34

6.59

4.50e-15

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005125

Cytokine activity

11 of 118

2.26

8.55

6.47e-22

GO:0070700

BMP receptor binding

7 of 13

3.02

8.55

8.19e-17

GO:0008083

Growth factor activity

9 of 141

2.09

6.06

6.14e-16

GO:0039706

Co-receptor binding

2 of 7

2.74

1.49

0.0019

GO:0036122

BMP binding

2 of 11

2.55

1.32

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005615

Extracellular space

11 of 1221

1.24

1.98

2.76e-11

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35923711

(2022) Genome-wide identification, characterization and expression analysis of the BMP family associated with beak-like teeth in Oplegnathus.

6 of 14

2.92

6.59

4.08e-13

PMID:27609345

(2016) The genome of the largest bony fish, ocean sunfish (Mola mola), provides insights into its fast growth rate.

5 of 60

2.21

3.34

1.53e-07

PMID:26952007

(2016) Goldfish morphology as a model for evolutionary developmental biology.

3 of 6

2.99

2.78

8.60e-06

PMID:33463017

(2020) Changes in Nkx2.1, Sox2, Bmp4, and Bmp16 expression underlying the lung-to-gas bladder evolutionary transition in ray-finned fishes.

3 of 14

2.62

2.36

4.29e-05

PMID:25238963

(2014) Negative feedback regulation of Wnt signaling via N-linked fucosylation in zebrafish.

3 of 13

2.65

2.36

4.29e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23582

TGF-beta, propeptide, and BMP binding

11 of 28

2.88

13.57

7.29e-28

CL:23584

TGF-beta, propeptide, and Activin types I and II receptor domain

8 of 22

2.85

9.43

4.60e-19

CL:23586

Activin types I and II receptor domain, and BMP receptor binding

7 of 17

2.9

8.32

1.31e-16

CL:23588

Activin types I and II receptor domain, and Cell proliferation involved in kidney development

4 of 11

2.85

4.13

2.18e-08

CL:23590

Activin types I and II receptor domain, and Cell proliferation involved in kidney development

2 of 6

2.81

1.42

0.0026

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tru04350

TGF-beta signaling pathway

11 of 110

2.29

9.16

1.97e-23

tru04060

Cytokine-cytokine receptor interaction

9 of 176

2.0

5.6

1.00e-15

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2129379

Molecules associated with elastic fibres

8 of 44

2.55

7.66

1.88e-16

MAP-1566948

Elastic fibre formation

8 of 57

2.44

7.17

6.30e-16

MAP-1474244

Extracellular matrix organization

8 of 424

1.56

2.72

2.24e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005576

Extracellular region

6 of 1157

1.0

0.65

0.0140

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0339

Growth factor

9 of 95

2.27

7.19

1.93e-17

KW-0964

Secreted

9 of 231

1.88

4.79

2.17e-14

KW-1015

Disulfide bond

10 of 1039

1.27

2.03

9.00e-11

KW-0732

Signal

9 of 2128

0.91

0.96

3.70e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00688

TGF-beta propeptide

9 of 35

2.7

9.63

3.47e-20

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001111

TGF-beta, propeptide

9 of 26

2.83

10.33

4.56e-21

IPR029034

Cystine-knot cytokine

11 of 72

2.47

10.25

9.14e-24

IPR017948

Transforming growth factor beta, conserved site

9 of 32

2.74

9.89

1.51e-20

IPR015615

Transforming growth factor-beta-related

9 of 32

2.74

9.89

1.51e-20

IPR001839

Transforming growth factor-beta, C-terminal

9 of 37

2.67

9.61

2.84e-20

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00204

Transforming growth factor-beta (TGF-beta) family

9 of 47

2.57

9.04

1.25e-19

SM00041

C-terminal cystine knot-like domain (CTCK)

2 of 20

2.29

0.91

0.0214

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