smad9 protein (Monopterus albus) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

smad9

Mothers against decapentaplegic homolog. (464 aa)

Predicted Functional Partners:

LOC109961575

0.977

SMAD4

0.977

ENSMALP00000022575

0.973

LOC109974571

0.972

LOC109968016

0.969

bmpr1a

0.965

bmpr1b

0.963

LOC109970815

0.963

smad6

0.950

smad7

0.950

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMALP00000022575	LOC109968016	ENSMALP00000022575	ENSMALP00000026409	MH1 domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.504
ENSMALP00000022575	LOC109970815	ENSMALP00000022575	ENSMALP00000017152	MH1 domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.545
ENSMALP00000022575	bmpr1a	ENSMALP00000022575	ENSMALP00000021173	MH1 domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.545
ENSMALP00000022575	bmpr1b	ENSMALP00000022575	ENSMALP00000016019	MH1 domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.545
ENSMALP00000022575	smad6	ENSMALP00000022575	ENSMALP00000010572	MH1 domain-containing protein.	Mothers against decapentaplegic homolog.	0.451
ENSMALP00000022575	smad7	ENSMALP00000022575	ENSMALP00000029659	MH1 domain-containing protein.	Mothers against decapentaplegic homolog.	0.451
ENSMALP00000022575	smad9	ENSMALP00000022575	ENSMALP00000015081	MH1 domain-containing protein.	Mothers against decapentaplegic homolog.	0.973
LOC109961575	LOC109968016	ENSMALP00000013623	ENSMALP00000026409	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.595
LOC109961575	LOC109970815	ENSMALP00000013623	ENSMALP00000017152	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.545
LOC109961575	bmpr1a	ENSMALP00000013623	ENSMALP00000021173	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.568
LOC109961575	bmpr1b	ENSMALP00000013623	ENSMALP00000016019	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.545
LOC109961575	smad6	ENSMALP00000013623	ENSMALP00000010572	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.451
LOC109961575	smad7	ENSMALP00000013623	ENSMALP00000029659	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.451
LOC109961575	smad9	ENSMALP00000013623	ENSMALP00000015081	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.977
LOC109968016	ENSMALP00000022575	ENSMALP00000026409	ENSMALP00000022575	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	MH1 domain-containing protein.	0.504
LOC109968016	LOC109961575	ENSMALP00000026409	ENSMALP00000013623	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.595
LOC109968016	LOC109974571	ENSMALP00000026409	ENSMALP00000027982	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.504
LOC109968016	SMAD4	ENSMALP00000026409	ENSMALP00000017441	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.595
LOC109968016	bmpr1a	ENSMALP00000026409	ENSMALP00000021173	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.650
LOC109968016	smad6	ENSMALP00000026409	ENSMALP00000010572	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.685

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Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.945

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033014

Tetrapyrrole biosynthetic process

10 of 55

2.15

6.87

5.45e-18

GO:0009236

Cobalamin biosynthetic process

7 of 25

2.33

5.69

8.69e-13

GO:0032259

Methylation

6 of 129

1.56

2.2

6.69e-07

GO:0019354

Siroheme biosynthetic process

2 of 2

2.89

1.79

0.00057

GO:0044237

Cellular metabolic process

11 of 3009

0.45

0.38

0.00063

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008757

S-adenosylmethionine-dependent methyltransferase activity

5 of 36

2.03

2.86

8.29e-07

GO:0008168

Methyltransferase activity

6 of 127

1.56

2.08

2.56e-06

GO:0046025

precorrin-6Y C5,15-methyltransferase (decarboxylating) activity

2 of 3

2.71

1.36

0.0034

GO:0008276

Protein methyltransferase activity

2 of 12

2.11

0.86

0.0249

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5071

Cobalamin metabolic process

9 of 18

2.59

8.96

2.59e-19

CL:5065

Tetrapyrrole biosynthetic process, and Sulfate assimilation

11 of 63

2.13

7.44

1.93e-20

CL:5073

Tetrapyrrole methylase, subdomain 2, and Cobalamin metabolic process

5 of 6

2.81

5.21

1.59e-10

CL:5163

Sulfate assimilation, and Siroheme metabolic process

2 of 11

2.15

0.83

0.0285

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00860

Porphyrin and chlorophyll metabolism

10 of 104

1.87

5.18

1.99e-16

map01100

Metabolic pathways

11 of 3119

0.44

0.36

0.0012

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031515

tRNA (m1A) methyltransferase complex

2 of 11

2.15

0.75

0.0412

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0489

Methyltransferase

5 of 138

1.45

1.5

0.00012

KW-0949

S-adenosyl-L-methionine

3 of 33

1.85

1.42

0.0013

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00590

Tetrapyrrole (Corrin/Porphyrin) Methylases

5 of 8

2.68

4.65

1.50e-09

PF01903

CbiX

2 of 3

2.71

1.18

0.0071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035996

Tetrapyrrole methylase superfamily

5 of 8

2.68

4.45

3.78e-09

IPR014777

Tetrapyrrole methylase, subdomain 1

5 of 8

2.68

4.45

3.78e-09

IPR000878

Tetrapyrrole methylase

5 of 8

2.68

4.45

3.78e-09

IPR014776

Tetrapyrrole methylase, subdomain 2

4 of 7

2.64

3.48

2.94e-07

IPR003043

Uroporphiryn-III C-methyltransferase, conserved site

2 of 3

2.71

1.18

0.0072

(more ...)

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