node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSMALP00000001140 | Fancm | ENSMALP00000001140 | ENSMALP00000018889 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Helicase ATP-binding domain-containing protein. | 0.678 |
ENSMALP00000001140 | ercc4 | ENSMALP00000001140 | ENSMALP00000013633 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Excision repair cross-complementation group 4. | 0.505 |
ENSMALP00000001140 | lig4 | ENSMALP00000001140 | ENSMALP00000012046 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | DNA ligase. | 0.434 |
ENSMALP00000001140 | mus81 | ENSMALP00000001140 | ENSMALP00000011813 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | MUS81 structure-specific endonuclease subunit. | 0.641 |
ENSMALP00000001140 | tdp1 | ENSMALP00000001140 | ENSMALP00000021079 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Tyrosyl-DNA phosphodiesterase 1. | 0.794 |
ENSMALP00000001140 | xrcc5 | ENSMALP00000001140 | ENSMALP00000024722 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.488 |
ENSMALP00000001140 | xrcc6 | ENSMALP00000001140 | ENSMALP00000019931 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | X-ray repair complementing defective repair in Chinese hamster cells 6. | 0.481 |
Fancm | ENSMALP00000001140 | ENSMALP00000018889 | ENSMALP00000001140 | Helicase ATP-binding domain-containing protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.678 |
Fancm | ercc4 | ENSMALP00000018889 | ENSMALP00000013633 | Helicase ATP-binding domain-containing protein. | Excision repair cross-complementation group 4. | 0.839 |
Fancm | lig3 | ENSMALP00000018889 | ENSMALP00000015715 | Helicase ATP-binding domain-containing protein. | DNA ligase. | 0.645 |
Fancm | lig4 | ENSMALP00000018889 | ENSMALP00000012046 | Helicase ATP-binding domain-containing protein. | DNA ligase. | 0.757 |
Fancm | mus81 | ENSMALP00000018889 | ENSMALP00000011813 | Helicase ATP-binding domain-containing protein. | MUS81 structure-specific endonuclease subunit. | 0.999 |
Fancm | tdp1 | ENSMALP00000018889 | ENSMALP00000021079 | Helicase ATP-binding domain-containing protein. | Tyrosyl-DNA phosphodiesterase 1. | 0.812 |
Fancm | xrcc1 | ENSMALP00000018889 | ENSMALP00000014988 | Helicase ATP-binding domain-containing protein. | X-ray repair complementing defective repair in Chinese hamster cells 1. | 0.589 |
Fancm | xrcc5 | ENSMALP00000018889 | ENSMALP00000024722 | Helicase ATP-binding domain-containing protein. | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.728 |
Fancm | xrcc6 | ENSMALP00000018889 | ENSMALP00000019931 | Helicase ATP-binding domain-containing protein. | X-ray repair complementing defective repair in Chinese hamster cells 6. | 0.770 |
ercc4 | ENSMALP00000001140 | ENSMALP00000013633 | ENSMALP00000001140 | Excision repair cross-complementation group 4. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.505 |
ercc4 | Fancm | ENSMALP00000013633 | ENSMALP00000018889 | Excision repair cross-complementation group 4. | Helicase ATP-binding domain-containing protein. | 0.839 |
ercc4 | lig4 | ENSMALP00000013633 | ENSMALP00000012046 | Excision repair cross-complementation group 4. | DNA ligase. | 0.720 |
ercc4 | mus81 | ENSMALP00000013633 | ENSMALP00000011813 | Excision repair cross-complementation group 4. | MUS81 structure-specific endonuclease subunit. | 0.969 |