phtf2 protein (Monopterus albus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

phtf2

Putative homeodomain transcription factor 2. (764 aa)

Predicted Functional Partners:

MSL3

0.781

MSL2

0.652

LOC109969631

0.652

ENSMALP00000003176

0.493

LOC109963669

0.476

LOC109953320

0.476

kat8

0.476

kat6a

0.476

kat5

0.476

kat6b

0.476

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMALP00000003176	phtf2	ENSMALP00000003176	ENSMALP00000022034	Mastermind-like transcriptional coactivator 1.	Putative homeodomain transcription factor 2.	0.493
LOC109953320	LOC109969631	ENSMALP00000017388	ENSMALP00000015587	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	MSL complex subunit 2.	0.739
LOC109953320	MSL2	ENSMALP00000017388	ENSMALP00000014380	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	MSL complex subunit 2.	0.739
LOC109953320	MSL3	ENSMALP00000017388	ENSMALP00000014654	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	MSL complex subunit 3.	0.810
LOC109953320	phtf2	ENSMALP00000017388	ENSMALP00000022034	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Putative homeodomain transcription factor 2.	0.476
LOC109963669	LOC109969631	ENSMALP00000005465	ENSMALP00000015587	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	MSL complex subunit 2.	0.739
LOC109963669	MSL2	ENSMALP00000005465	ENSMALP00000014380	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	MSL complex subunit 2.	0.739
LOC109963669	MSL3	ENSMALP00000005465	ENSMALP00000014654	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	MSL complex subunit 3.	0.810
LOC109963669	phtf2	ENSMALP00000005465	ENSMALP00000022034	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Putative homeodomain transcription factor 2.	0.476
LOC109969631	LOC109953320	ENSMALP00000015587	ENSMALP00000017388	MSL complex subunit 2.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.739
LOC109969631	LOC109963669	ENSMALP00000015587	ENSMALP00000005465	MSL complex subunit 2.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.739
LOC109969631	MSL3	ENSMALP00000015587	ENSMALP00000014654	MSL complex subunit 2.	MSL complex subunit 3.	0.977
LOC109969631	kat5	ENSMALP00000015587	ENSMALP00000024744	MSL complex subunit 2.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.826
LOC109969631	kat6a	ENSMALP00000015587	ENSMALP00000022120	MSL complex subunit 2.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.739
LOC109969631	kat6b	ENSMALP00000015587	ENSMALP00000032589	MSL complex subunit 2.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.739
LOC109969631	kat8	ENSMALP00000015587	ENSMALP00000020946	MSL complex subunit 2.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.826
LOC109969631	phtf2	ENSMALP00000015587	ENSMALP00000022034	MSL complex subunit 2.	Putative homeodomain transcription factor 2.	0.652
MSL2	LOC109953320	ENSMALP00000014380	ENSMALP00000017388	MSL complex subunit 2.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.739
MSL2	LOC109963669	ENSMALP00000014380	ENSMALP00000005465	MSL complex subunit 2.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.739
MSL2	MSL3	ENSMALP00000014380	ENSMALP00000014654	MSL complex subunit 2.	MSL complex subunit 3.	0.977

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.871

expected number of edges:

12

PPI enrichment p-value:

0.0535

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005986

Sucrose biosynthetic process

2 of 2

3.28

1.07

0.0121

GO:0006002

Fructose 6-phosphate metabolic process

2 of 9

2.62

1.05

0.0125

GO:0030388

Fructose 1,6-bisphosphate metabolic process

2 of 11

2.54

1.04

0.0125

GO:0006000

Fructose metabolic process

2 of 11

2.54

1.04

0.0125

GO:0036158

Outer dynein arm assembly

2 of 14

2.43

1.02

0.0134

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0047617

acyl-CoA hydrolase activity

3 of 24

2.37

1.65

0.00084

GO:0042132

Fructose 1,6-bisphosphate 1-phosphatase activity

2 of 2

3.28

1.6

0.0013

GO:0004784

Superoxide dismutase activity

2 of 3

3.1

1.58

0.0014

GO:0045504

Dynein heavy chain binding

2 of 15

2.4

1.03

0.0129

GO:0005507

Copper ion binding

2 of 38

2.0

0.71

0.0468

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030286

Dynein complex

3 of 56

2.01

1.22

0.0044

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3046

Dynein heavy chain binding, and Dynein light chain type 1

3 of 5

3.05

2.52

2.69e-05

CL:34035

Acyl-CoA thioesterase, long chain, and Thioesterase domain

3 of 7

2.91

2.49

2.88e-05

CL:24468

Superoxide dismutase activity, and Regulation of oxidative phosphorylation uncoupler activity

2 of 5

2.88

1.37

0.0033

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00062

Fatty acid elongation

3 of 51

2.05

1.67

0.00052

map01040

Biosynthesis of unsaturated fatty acids

3 of 63

1.95

1.64

0.00052

map00051

Fructose and mannose metabolism

2 of 63

1.78

0.82

0.0258

map00030

Pentose phosphate pathway

2 of 55

1.84

0.82

0.0258

map00010

Glycolysis / Gluconeogenesis

2 of 99

1.58

0.66

0.0484

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0036157

Outer dynein arm

2 of 4

2.98

1.33

0.0040

GOCC:0030286

Dynein complex

3 of 51

2.05

1.25

0.0040

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0186

Copper

2 of 9

2.62

1.28

0.0046

KW-0119

Carbohydrate metabolism

2 of 33

2.06

0.86

0.0246

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00316

Fructose-1-6-bisphosphatase, N-terminal domain

2 of 2

3.28

1.38

0.0033

PF00080

Copper/zinc superoxide dismutase (SODC)

2 of 3

3.1

1.38

0.0033

PF08840

BAAT / Acyl-CoA thioester hydrolase C terminal

2 of 4

2.98

1.37

0.0033

PF04775

Acyl-CoA thioester hydrolase/BAAT N-terminal region

2 of 8

2.67

1.21

0.0062

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044015

Fructose-1-6-bisphosphatase class 1, C-terminal

2 of 2

3.28

1.1

0.0106

IPR036423

Superoxide dismutase-like, copper/zinc binding domain superfamily

2 of 3

3.1

1.1

0.0106

IPR033391

Fructose-1-6-bisphosphatase class I, N-terminal

2 of 2

3.28

1.1

0.0106

IPR028343

Fructose-1,6-bisphosphatase

2 of 2

3.28

1.1

0.0106

IPR024134

Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone

2 of 3

3.1

1.1

0.0106

(more ...)

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