LOC109967487 protein (Monopterus albus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC109967487

WD_REPEATS_REGION domain-containing protein. (488 aa)

Predicted Functional Partners:

mad2l1

0.995

anapc2

0.987

cdc27

0.987

cdc16

0.985

cdc23

0.985

anapc7

0.980

anapc10

0.979

anapc13

0.976

LOC109956601

0.976

cdc26

0.974

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC109956601	LOC109967487	ENSMALP00000025418	ENSMALP00000022258	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.976
LOC109956601	anapc10	ENSMALP00000025418	ENSMALP00000006321	Uncharacterized protein.	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	0.908
LOC109956601	anapc13	ENSMALP00000025418	ENSMALP00000010785	Uncharacterized protein.	Anaphase promoting complex subunit 13.	0.902
LOC109956601	anapc2	ENSMALP00000025418	ENSMALP00000021019	Uncharacterized protein.	Anaphase promoting complex subunit 2; Belongs to the cullin family.	0.906
LOC109956601	anapc7	ENSMALP00000025418	ENSMALP00000004318	Uncharacterized protein.	Anaphase promoting complex subunit 7.	0.901
LOC109956601	cdc16	ENSMALP00000025418	ENSMALP00000003391	Uncharacterized protein.	Cell division cycle 16 homolog (S. cerevisiae).	0.933
LOC109956601	cdc23	ENSMALP00000025418	ENSMALP00000022336	Uncharacterized protein.	CDC23 (cell division cycle 23, yeast, homolog).	0.935
LOC109956601	cdc26	ENSMALP00000025418	ENSMALP00000019485	Uncharacterized protein.	Cell division cycle 26 homolog.	0.901
LOC109956601	cdc27	ENSMALP00000025418	ENSMALP00000023462	Uncharacterized protein.	Cell division cycle 27.	0.936
LOC109956601	mad2l1	ENSMALP00000025418	ENSMALP00000028282	Uncharacterized protein.	MAD2 mitotic arrest deficient-like 1 (yeast).	0.575
LOC109967487	LOC109956601	ENSMALP00000022258	ENSMALP00000025418	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.976
LOC109967487	anapc10	ENSMALP00000022258	ENSMALP00000006321	WD_REPEATS_REGION domain-containing protein.	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	0.979
LOC109967487	anapc13	ENSMALP00000022258	ENSMALP00000010785	WD_REPEATS_REGION domain-containing protein.	Anaphase promoting complex subunit 13.	0.976
LOC109967487	anapc2	ENSMALP00000022258	ENSMALP00000021019	WD_REPEATS_REGION domain-containing protein.	Anaphase promoting complex subunit 2; Belongs to the cullin family.	0.987
LOC109967487	anapc7	ENSMALP00000022258	ENSMALP00000004318	WD_REPEATS_REGION domain-containing protein.	Anaphase promoting complex subunit 7.	0.980
LOC109967487	cdc16	ENSMALP00000022258	ENSMALP00000003391	WD_REPEATS_REGION domain-containing protein.	Cell division cycle 16 homolog (S. cerevisiae).	0.985
LOC109967487	cdc23	ENSMALP00000022258	ENSMALP00000022336	WD_REPEATS_REGION domain-containing protein.	CDC23 (cell division cycle 23, yeast, homolog).	0.985
LOC109967487	cdc26	ENSMALP00000022258	ENSMALP00000019485	WD_REPEATS_REGION domain-containing protein.	Cell division cycle 26 homolog.	0.974
LOC109967487	cdc27	ENSMALP00000022258	ENSMALP00000023462	WD_REPEATS_REGION domain-containing protein.	Cell division cycle 27.	0.987
LOC109967487	mad2l1	ENSMALP00000022258	ENSMALP00000028282	WD_REPEATS_REGION domain-containing protein.	MAD2 mitotic arrest deficient-like 1 (yeast).	0.995

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

43

PPI enrichment p-value:

0.736

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030176

Integral component of endoplasmic reticulum membrane

3 of 132

1.63

0.79

0.0265

GO:0005615

Extracellular space

6 of 1087

1.02

0.69

0.0095

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4709

Mixed, incl. Lipolysis stimulated receptor (LSR), and Kringle

6 of 10

3.05

6.91

1.44e-13

CL:4713

Kringle, and Establishment of epithelial cell apical/basal polarity

4 of 5

3.18

4.72

2.48e-09

CL:4690

Immunoglobulin C-2 Type, and Leucine rich repeat N-terminal domain

7 of 143

1.97

4.0

2.48e-10

CL:4409

MHC I, and MHC class I-like antigen recognition-like superfamily

2 of 6

2.8

1.44

0.0024

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0420

Kringle

3 of 19

2.47

2.27

5.53e-05

KW-0720

Serine protease

3 of 80

1.85

1.38

0.0016

KW-1015

Disulfide bond

6 of 1146

1.0

0.81

0.0016

KW-0245

EGF-like domain

3 of 226

1.4

0.8

0.0167

KW-0964

Secreted

3 of 242

1.37

0.79

0.0167

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038178

Kringle superfamily

3 of 19

2.47

1.77

0.00052

IPR000001

Kringle

3 of 19

2.47

1.77

0.00052

IPR013806

Kringle-like fold

3 of 28

2.31

1.74

0.00052

IPR003591

Leucine-rich repeat, typical subtype

5 of 199

1.68

1.6

0.00026

IPR001611

Leucine-rich repeat

5 of 270

1.54

1.4

0.00052

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00130

Kringle domain

3 of 19

2.47

2.24

6.46e-05

SM00013

Leucine rich repeat N-terminal domain

4 of 117

1.81

1.88

8.90e-05

SM00370

Leucine-rich repeats, outliers

5 of 233

1.61

1.75

6.30e-05

SM00369

Leucine-rich repeats, typical (most populated) subfamily

4 of 160

1.67

1.62

0.00023

SM00020

Trypsin-like serine protease

3 of 97

1.77

1.25

0.0027

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About