LOC109971511 protein (Monopterus albus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC109971511

SRY-box transcription factor 32. (338 aa)

Predicted Functional Partners:

LOC109969955

0.606

LOC109953710

0.604

LOC109960702

0.468

LOC109970446

0.461

gata6

0.438

ENSMALP00000027025

0.410

LOC109968582

0.406

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMALP00000027025	LOC109953710	ENSMALP00000027025	ENSMALP00000005547	POU domain protein.	Mix paired-like homeobox.	0.410
ENSMALP00000027025	LOC109968582	ENSMALP00000027025	ENSMALP00000023735	POU domain protein.	T-box transcription factor Ta.	0.673
ENSMALP00000027025	LOC109971511	ENSMALP00000027025	ENSMALP00000024049	POU domain protein.	SRY-box transcription factor 32.	0.410
ENSMALP00000027025	gata6	ENSMALP00000027025	ENSMALP00000031362	POU domain protein.	GATA binding protein 6.	0.462
LOC109953710	ENSMALP00000027025	ENSMALP00000005547	ENSMALP00000027025	Mix paired-like homeobox.	POU domain protein.	0.410
LOC109953710	LOC109960702	ENSMALP00000005547	ENSMALP00000001783	Mix paired-like homeobox.	Teratocarcinoma-derived growth factor 1.	0.435
LOC109953710	LOC109968582	ENSMALP00000005547	ENSMALP00000023735	Mix paired-like homeobox.	T-box transcription factor Ta.	0.640
LOC109953710	LOC109969955	ENSMALP00000005547	ENSMALP00000002246	Mix paired-like homeobox.	GATA binding protein 5.	0.499
LOC109953710	LOC109971511	ENSMALP00000005547	ENSMALP00000024049	Mix paired-like homeobox.	SRY-box transcription factor 32.	0.604
LOC109960702	LOC109953710	ENSMALP00000001783	ENSMALP00000005547	Teratocarcinoma-derived growth factor 1.	Mix paired-like homeobox.	0.435
LOC109960702	LOC109968582	ENSMALP00000001783	ENSMALP00000023735	Teratocarcinoma-derived growth factor 1.	T-box transcription factor Ta.	0.500
LOC109960702	LOC109971511	ENSMALP00000001783	ENSMALP00000024049	Teratocarcinoma-derived growth factor 1.	SRY-box transcription factor 32.	0.468
LOC109968582	ENSMALP00000027025	ENSMALP00000023735	ENSMALP00000027025	T-box transcription factor Ta.	POU domain protein.	0.673
LOC109968582	LOC109953710	ENSMALP00000023735	ENSMALP00000005547	T-box transcription factor Ta.	Mix paired-like homeobox.	0.640
LOC109968582	LOC109960702	ENSMALP00000023735	ENSMALP00000001783	T-box transcription factor Ta.	Teratocarcinoma-derived growth factor 1.	0.500
LOC109968582	LOC109971511	ENSMALP00000023735	ENSMALP00000024049	T-box transcription factor Ta.	SRY-box transcription factor 32.	0.406
LOC109968582	gata6	ENSMALP00000023735	ENSMALP00000031362	T-box transcription factor Ta.	GATA binding protein 6.	0.412
LOC109969955	LOC109953710	ENSMALP00000002246	ENSMALP00000005547	GATA binding protein 5.	Mix paired-like homeobox.	0.499
LOC109969955	LOC109970446	ENSMALP00000002246	ENSMALP00000025187	GATA binding protein 5.	Homeobox domain-containing protein.	0.478
LOC109969955	LOC109971511	ENSMALP00000002246	ENSMALP00000024049	GATA binding protein 5.	SRY-box transcription factor 32.	0.606

page 1 of 2

Network Stats

number of nodes:

7

number of edges:

15

average node degree:

4.29

avg. local clustering coefficient:

0.9

expected number of edges:

6

PPI enrichment p-value:

0.0014

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

9 of 355

1.68

3.36

5.08e-11

GO:0006511

Ubiquitin-dependent protein catabolic process

10 of 585

1.51

2.8

5.08e-11

GO:0042176

Regulation of protein catabolic process

5 of 347

1.43

1.34

0.00040

GO:0019538

Protein metabolic process

11 of 4202

0.69

0.63

2.05e-05

GO:0044237

Cellular metabolic process

11 of 6814

0.48

0.38

0.0028

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036402

Proteasome-activating activity

4 of 7

3.03

3.99

4.85e-08

GO:0017025

TBP-class protein binding

3 of 28

2.3

1.63

0.00085

GO:0016887

ATP hydrolysis activity

4 of 316

1.37

0.82

0.0145

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005838

Proteasome regulatory particle

10 of 22

2.93

12.49

3.18e-25

GO:0008540

Proteasome regulatory particle, base subcomplex

5 of 12

2.89

5.69

2.25e-11

GO:0008541

Proteasome regulatory particle, lid subcomplex

3 of 8

2.85

2.97

3.53e-06

GO:0031595

Nuclear proteasome complex

2 of 3

3.1

1.86

0.00044

GO:0031597

Cytosolic proteasome complex

2 of 8

2.67

1.5

0.0018

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:475

Proteasome regulatory particle

9 of 14

3.08

12.06

1.11e-23

CL:471

Proteasome

10 of 30

2.8

11.78

1.85e-24

CL:461

Cross-presentation of soluble exogenous antigens (endosomes)

11 of 50

2.61

11.47

2.67e-25

CL:478

Proteasome regulatory particle

4 of 7

3.03

4.5

5.48e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ccan03050

Proteasome

10 of 44

2.63

10.76

2.29e-23

ccan05017

Spinocerebellar ataxia

10 of 127

2.17

7.36

2.19e-19

ccan05169

Epstein-Barr virus infection

10 of 174

2.03

6.38

3.03e-18

ccan05012

Parkinson disease

10 of 217

1.94

5.7

1.95e-17

ccan05020

Prion disease

10 of 227

1.92

5.59

2.42e-17

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236978

Cross-presentation of soluble exogenous antigens (endosomes)

10 of 55

2.53

9.77

8.83e-22

MAP-75815

Ubiquitin-dependent degradation of Cyclin D

10 of 60

2.49

9.61

9.78e-22

MAP-69613

p53-Independent G1/S DNA damage checkpoint

10 of 60

2.49

9.61

9.78e-22

MAP-69610

p53-Independent DNA Damage Response

10 of 60

2.49

9.61

9.78e-22

MAP-69601

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

10 of 60

2.49

9.61

9.78e-22

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000502

Proteasome complex

11 of 76

2.43

10.08

7.64e-24

GOCC:0022624

Proteasome accessory complex

6 of 16

2.85

6.74

1.57e-13

GOCC:0005838

Proteasome regulatory particle

5 of 9

3.02

5.9

1.16e-11

GOCC:0008541

Proteasome regulatory particle, lid subcomplex

3 of 6

2.97

3.05

2.63e-06

GOCC:0031595

Nuclear proteasome complex

2 of 3

3.1

1.8

0.00056

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0647

Proteasome

4 of 43

2.24

2.78

3.22e-06

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00088

Motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

3 of 14

2.6

2.28

5.99e-05

SM00382

ATPases associated with a variety of cellular activities

4 of 116

1.81

1.8

0.00014

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About