LOC109957090 protein (Monopterus albus) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

LOC109957090

HEPN domain-containing protein. (4184 aa)

Predicted Functional Partners:

incenp

0.808

aurka

0.765

Fbxl12

0.765

atp5f1b

0.745

cdca8

0.745

LOC109953201

0.719

LOC109969732

0.719

apaf1

0.711

LOC109970306

0.660

tradd

0.653

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Fbxl12	LOC109957090	ENSMALP00000026725	ENSMALP00000025428	Aurora kinase B; Belongs to the protein kinase superfamily.	HEPN domain-containing protein.	0.765
Fbxl12	apaf1	ENSMALP00000026725	ENSMALP00000016325	Aurora kinase B; Belongs to the protein kinase superfamily.	Apoptotic peptidase activating factor 1.	0.670
Fbxl12	atp5f1b	ENSMALP00000026725	ENSMALP00000015733	Aurora kinase B; Belongs to the protein kinase superfamily.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.882
Fbxl12	aurka	ENSMALP00000026725	ENSMALP00000014955	Aurora kinase B; Belongs to the protein kinase superfamily.	Aurora kinase A; Belongs to the protein kinase superfamily.	0.409
Fbxl12	cdca8	ENSMALP00000026725	ENSMALP00000016675	Aurora kinase B; Belongs to the protein kinase superfamily.	Cell division cycle associated 8.	0.958
Fbxl12	incenp	ENSMALP00000026725	ENSMALP00000006858	Aurora kinase B; Belongs to the protein kinase superfamily.	INCENP_N domain-containing protein.	0.986
LOC109953201	LOC109957090	ENSMALP00000011641	ENSMALP00000025428	Diablo, IAP-binding mitochondrial protein a.	HEPN domain-containing protein.	0.719
LOC109953201	LOC109969732	ENSMALP00000011641	ENSMALP00000022942	Diablo, IAP-binding mitochondrial protein a.	Diablo, IAP-binding mitochondrial protein a.	0.901
LOC109953201	apaf1	ENSMALP00000011641	ENSMALP00000016325	Diablo, IAP-binding mitochondrial protein a.	Apoptotic peptidase activating factor 1.	0.829
LOC109957090	Fbxl12	ENSMALP00000025428	ENSMALP00000026725	HEPN domain-containing protein.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.765
LOC109957090	LOC109953201	ENSMALP00000025428	ENSMALP00000011641	HEPN domain-containing protein.	Diablo, IAP-binding mitochondrial protein a.	0.719
LOC109957090	LOC109969732	ENSMALP00000025428	ENSMALP00000022942	HEPN domain-containing protein.	Diablo, IAP-binding mitochondrial protein a.	0.719
LOC109957090	LOC109970306	ENSMALP00000025428	ENSMALP00000019610	HEPN domain-containing protein.	Ubiquitin-conjugating enzyme E2 variant 1.	0.660
LOC109957090	apaf1	ENSMALP00000025428	ENSMALP00000016325	HEPN domain-containing protein.	Apoptotic peptidase activating factor 1.	0.711
LOC109957090	atp5f1b	ENSMALP00000025428	ENSMALP00000015733	HEPN domain-containing protein.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.745
LOC109957090	aurka	ENSMALP00000025428	ENSMALP00000014955	HEPN domain-containing protein.	Aurora kinase A; Belongs to the protein kinase superfamily.	0.765
LOC109957090	cdca8	ENSMALP00000025428	ENSMALP00000016675	HEPN domain-containing protein.	Cell division cycle associated 8.	0.745
LOC109957090	incenp	ENSMALP00000025428	ENSMALP00000006858	HEPN domain-containing protein.	INCENP_N domain-containing protein.	0.808
LOC109957090	tradd	ENSMALP00000025428	ENSMALP00000000883	HEPN domain-containing protein.	Tnfrsf1a-associated via death domain.	0.653
LOC109969732	LOC109953201	ENSMALP00000022942	ENSMALP00000011641	Diablo, IAP-binding mitochondrial protein a.	Diablo, IAP-binding mitochondrial protein a.	0.901

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Network Stats

number of nodes:

5

number of edges:

9

average node degree:

3.6

avg. local clustering coefficient:

0.9

expected number of edges:

4

PPI enrichment p-value:

0.0196

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006470

Protein dephosphorylation

4 of 5

2.56

3.01

2.14e-06

GO:0036211

Protein modification process

6 of 158

1.24

1.22

0.00020

GO:0006796

Phosphate-containing compound metabolic process

7 of 382

0.92

0.76

0.0013

GO:1901564

Organonitrogen compound metabolic process

8 of 919

0.6

0.39

0.0214

GO:0006807

Nitrogen compound metabolic process

9 of 1386

0.47

0.3

0.0446

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004722

Protein serine/threonine phosphatase activity

4 of 7

2.42

2.87

3.25e-06

GO:0140096

Catalytic activity, acting on a protein

6 of 295

0.97

0.76

0.0025

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3411

Mixed, incl. Protein dephosphorylation, and C-type lectin fold

5 of 13

2.25

3.38

1.49e-07

CL:3415

Protein dephosphorylation, and Protein kinase, ATP binding site

4 of 6

2.48

3.09

1.32e-06

CL:4540

HPT domain superfamily, and Cache 3/Cache 2 fusion domain

3 of 6

2.36

1.94

0.00022

CL:4491

His Kinase A (phosphoacceptor) domain, and GGDEF domain

4 of 62

1.47

1.18

0.0017

CL:4455

Signaling

5 of 147

1.19

0.98

0.0017

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03070

Bacterial secretion system

4 of 78

1.37

1.07

0.0025

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001932

PPM-type phosphatase-like domain

3 of 5

2.44

1.67

0.00079

IPR036457

PPM-type phosphatase-like domain superfamily

3 of 6

2.36

1.66

0.00079

IPR036641

HPT domain superfamily

3 of 8

2.23

1.63

0.00079

IPR015655

Protein phosphatase 2C family

2 of 2

2.66

1.06

0.0119

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00332

Serine/threonine phosphatases, family 2C, catalytic domain

2 of 3

2.48

1.22

0.0059

SM00331

Sigma factor PP2C-like phosphatases

2 of 4

2.36

1.21

0.0059

SM00073

Histidine Phosphotransfer domain

2 of 8

2.06

1.09

0.0087

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