LOC109962900 protein (Monopterus albus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

LOC109962900

Uncharacterized protein. (1421 aa)

Predicted Functional Partners:

ENSMALP00000022375

0.897

cdh23

0.791

ENSMALP00000006488

0.777

ush1c

0.580

ENSMALP00000008310

0.514

LOC109974769

0.514

Lhfpl3

0.514

LOC109971100

0.514

LOC109956116

0.514

lhfpl4

0.514

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMALP00000006488	ENSMALP00000022375	ENSMALP00000006488	ENSMALP00000022375	Uncharacterized protein.	Si:dkeyp-86d6.2.	0.777
ENSMALP00000006488	LOC109962900	ENSMALP00000006488	ENSMALP00000031467	Uncharacterized protein.	Uncharacterized protein.	0.777
ENSMALP00000006488	ush1c	ENSMALP00000006488	ENSMALP00000019511	Uncharacterized protein.	Usher syndrome 1C.	0.884
ENSMALP00000008310	ENSMALP00000022375	ENSMALP00000008310	ENSMALP00000022375	LHFPL tetraspan subfamily member 4a.	Si:dkeyp-86d6.2.	0.514
ENSMALP00000008310	LOC109962900	ENSMALP00000008310	ENSMALP00000031467	LHFPL tetraspan subfamily member 4a.	Uncharacterized protein.	0.514
ENSMALP00000022375	ENSMALP00000006488	ENSMALP00000022375	ENSMALP00000006488	Si:dkeyp-86d6.2.	Uncharacterized protein.	0.777
ENSMALP00000022375	ENSMALP00000008310	ENSMALP00000022375	ENSMALP00000008310	Si:dkeyp-86d6.2.	LHFPL tetraspan subfamily member 4a.	0.514
ENSMALP00000022375	LOC109956116	ENSMALP00000022375	ENSMALP00000030174	Si:dkeyp-86d6.2.	LHFPL tetraspan subfamily member 5a.	0.514
ENSMALP00000022375	LOC109962900	ENSMALP00000022375	ENSMALP00000031467	Si:dkeyp-86d6.2.	Uncharacterized protein.	0.897
ENSMALP00000022375	LOC109971100	ENSMALP00000022375	ENSMALP00000027806	Si:dkeyp-86d6.2.	LHFPL tetraspan subfamily member 5b.	0.514
ENSMALP00000022375	LOC109974769	ENSMALP00000022375	ENSMALP00000013181	Si:dkeyp-86d6.2.	Uncharacterized protein.	0.514
ENSMALP00000022375	Lhfpl3	ENSMALP00000022375	ENSMALP00000020778	Si:dkeyp-86d6.2.	LHFPL tetraspan subfamily member 3.	0.514
ENSMALP00000022375	cdh23	ENSMALP00000022375	ENSMALP00000009896	Si:dkeyp-86d6.2.	Cadherin-related 23.	0.791
ENSMALP00000022375	lhfpl4	ENSMALP00000022375	ENSMALP00000030583	Si:dkeyp-86d6.2.	LHFPL tetraspan subfamily member 4a.	0.514
ENSMALP00000022375	ush1c	ENSMALP00000022375	ENSMALP00000019511	Si:dkeyp-86d6.2.	Usher syndrome 1C.	0.580
LOC109956116	ENSMALP00000022375	ENSMALP00000030174	ENSMALP00000022375	LHFPL tetraspan subfamily member 5a.	Si:dkeyp-86d6.2.	0.514
LOC109956116	LOC109962900	ENSMALP00000030174	ENSMALP00000031467	LHFPL tetraspan subfamily member 5a.	Uncharacterized protein.	0.514
LOC109956116	cdh23	ENSMALP00000030174	ENSMALP00000009896	LHFPL tetraspan subfamily member 5a.	Cadherin-related 23.	0.426
LOC109962900	ENSMALP00000006488	ENSMALP00000031467	ENSMALP00000006488	Uncharacterized protein.	Uncharacterized protein.	0.777
LOC109962900	ENSMALP00000008310	ENSMALP00000031467	ENSMALP00000008310	Uncharacterized protein.	LHFPL tetraspan subfamily member 4a.	0.514

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.833

expected number of edges:

10

PPI enrichment p-value:

0.000135

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060393

Regulation of pathway-restricted SMAD protein phosphorylation

9 of 62

2.45

8.0

6.33e-18

GO:0010862

Positive regulation of pathway-restricted SMAD protein phosphorylation

8 of 50

2.49

7.33

5.80e-16

GO:0090100

Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

9 of 89

2.29

7.07

8.89e-17

GO:0060395

SMAD protein signal transduction

8 of 62

2.4

6.86

2.28e-15

GO:0030509

BMP signaling pathway

8 of 71

2.34

6.59

4.50e-15

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005125

Cytokine activity

11 of 118

2.26

8.55

6.47e-22

GO:0070700

BMP receptor binding

7 of 13

3.02

8.55

8.19e-17

GO:0008083

Growth factor activity

9 of 141

2.09

6.06

6.14e-16

GO:0039706

Co-receptor binding

2 of 7

2.74

1.49

0.0019

GO:0036122

BMP binding

2 of 11

2.55

1.32

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005615

Extracellular space

11 of 1221

1.24

1.98

2.76e-11

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35923711

(2022) Genome-wide identification, characterization and expression analysis of the BMP family associated with beak-like teeth in Oplegnathus.

6 of 14

2.92

6.59

4.08e-13

PMID:27609345

(2016) The genome of the largest bony fish, ocean sunfish (Mola mola), provides insights into its fast growth rate.

5 of 60

2.21

3.34

1.53e-07

PMID:26952007

(2016) Goldfish morphology as a model for evolutionary developmental biology.

3 of 6

2.99

2.78

8.60e-06

PMID:33463017

(2020) Changes in Nkx2.1, Sox2, Bmp4, and Bmp16 expression underlying the lung-to-gas bladder evolutionary transition in ray-finned fishes.

3 of 14

2.62

2.36

4.29e-05

PMID:25238963

(2014) Negative feedback regulation of Wnt signaling via N-linked fucosylation in zebrafish.

3 of 13

2.65

2.36

4.29e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23582

TGF-beta, propeptide, and BMP binding

11 of 28

2.88

13.57

7.29e-28

CL:23584

TGF-beta, propeptide, and Activin types I and II receptor domain

8 of 22

2.85

9.43

4.60e-19

CL:23586

Activin types I and II receptor domain, and BMP receptor binding

7 of 17

2.9

8.32

1.31e-16

CL:23588

Activin types I and II receptor domain, and Cell proliferation involved in kidney development

4 of 11

2.85

4.13

2.18e-08

CL:23590

Activin types I and II receptor domain, and Cell proliferation involved in kidney development

2 of 6

2.81

1.42

0.0026

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tru04350

TGF-beta signaling pathway

11 of 110

2.29

9.16

1.97e-23

tru04060

Cytokine-cytokine receptor interaction

9 of 176

2.0

5.6

1.00e-15

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2129379

Molecules associated with elastic fibres

8 of 44

2.55

7.66

1.88e-16

MAP-1566948

Elastic fibre formation

8 of 57

2.44

7.17

6.30e-16

MAP-1474244

Extracellular matrix organization

8 of 424

1.56

2.72

2.24e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005576

Extracellular region

6 of 1157

1.0

0.65

0.0140

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0339

Growth factor

9 of 95

2.27

7.19

1.93e-17

KW-0964

Secreted

9 of 231

1.88

4.79

2.17e-14

KW-1015

Disulfide bond

10 of 1039

1.27

2.03

9.00e-11

KW-0732

Signal

9 of 2128

0.91

0.96

3.70e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00688

TGF-beta propeptide

9 of 35

2.7

9.63

3.47e-20

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001111

TGF-beta, propeptide

9 of 26

2.83

10.33

4.56e-21

IPR029034

Cystine-knot cytokine

11 of 72

2.47

10.25

9.14e-24

IPR017948

Transforming growth factor beta, conserved site

9 of 32

2.74

9.89

1.51e-20

IPR015615

Transforming growth factor-beta-related

9 of 32

2.74

9.89

1.51e-20

IPR001839

Transforming growth factor-beta, C-terminal

9 of 37

2.67

9.61

2.84e-20

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00204

Transforming growth factor-beta (TGF-beta) family

9 of 47

2.57

9.04

1.25e-19

SM00041

C-terminal cystine knot-like domain (CTCK)

2 of 20

2.29

0.91

0.0214

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