LOC109952244 protein (Monopterus albus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LOC109952244

Zgc:152891. (678 aa)

Predicted Functional Partners:

PLA2G12B

0.922

CYP4F8

0.919

PTGS1

0.918

LOC109959089

0.918

pla2g4a

0.918

ptgs2

0.918

LOC109973708

0.911

LOC109960695

0.906

alox5

0.906

pla2g12a

0.906

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP4F8	LOC109952244	ENSMALP00000023238	ENSMALP00000031811	Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family.	Zgc:152891.	0.919
CYP4F8	LOC109959089	ENSMALP00000023238	ENSMALP00000009750	Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family.	Prostaglandin-endoperoxide synthase 1.	0.904
CYP4F8	LOC109960695	ENSMALP00000023238	ENSMALP00000003261	Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family.	Phospholipase A2, group XIIB.	0.901
CYP4F8	LOC109973708	ENSMALP00000023238	ENSMALP00000015980	Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family.	PLA2c domain-containing protein.	0.919
CYP4F8	PLA2G12B	ENSMALP00000023238	ENSMALP00000008094	Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family.	Phospholipase A2 group XIIB.	0.909
CYP4F8	PTGS1	ENSMALP00000023238	ENSMALP00000006360	Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family.	Prostaglandin-endoperoxide synthase 1.	0.904
CYP4F8	alox5	ENSMALP00000023238	ENSMALP00000026066	Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family.	Arachidonate 5-lipoxygenase a.	0.919
CYP4F8	pla2g12a	ENSMALP00000023238	ENSMALP00000032059	Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family.	Phospholipase A2, group XIIA.	0.901
CYP4F8	pla2g4a	ENSMALP00000023238	ENSMALP00000028410	Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family.	Phospholipase A2.	0.907
CYP4F8	ptgs2	ENSMALP00000023238	ENSMALP00000028444	Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family.	Prostaglandin-endoperoxide synthase 2b.	0.904
LOC109952244	CYP4F8	ENSMALP00000031811	ENSMALP00000023238	Zgc:152891.	Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family.	0.919
LOC109952244	LOC109959089	ENSMALP00000031811	ENSMALP00000009750	Zgc:152891.	Prostaglandin-endoperoxide synthase 1.	0.918
LOC109952244	LOC109960695	ENSMALP00000031811	ENSMALP00000003261	Zgc:152891.	Phospholipase A2, group XIIB.	0.906
LOC109952244	LOC109973708	ENSMALP00000031811	ENSMALP00000015980	Zgc:152891.	PLA2c domain-containing protein.	0.911
LOC109952244	PLA2G12B	ENSMALP00000031811	ENSMALP00000008094	Zgc:152891.	Phospholipase A2 group XIIB.	0.922
LOC109952244	PTGS1	ENSMALP00000031811	ENSMALP00000006360	Zgc:152891.	Prostaglandin-endoperoxide synthase 1.	0.918
LOC109952244	alox5	ENSMALP00000031811	ENSMALP00000026066	Zgc:152891.	Arachidonate 5-lipoxygenase a.	0.906
LOC109952244	pla2g12a	ENSMALP00000031811	ENSMALP00000032059	Zgc:152891.	Phospholipase A2, group XIIA.	0.906
LOC109952244	pla2g4a	ENSMALP00000031811	ENSMALP00000028410	Zgc:152891.	Phospholipase A2.	0.918
LOC109952244	ptgs2	ENSMALP00000031811	ENSMALP00000028444	Zgc:152891.	Prostaglandin-endoperoxide synthase 2b.	0.918

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Network Stats

number of nodes:

8

number of edges:

18

average node degree:

4.5

avg. local clustering coefficient:

0.624

expected number of edges:

7

PPI enrichment p-value:

0.000379

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003383

Apical constriction

3 of 4

3.15

2.49

3.06e-05

GO:0031032

Actomyosin structure organization

3 of 103

1.74

0.76

0.0328

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20317

Cadherin conserved site, and Plakophilin/Delta catenin

5 of 70

2.13

2.91

1.06e-06

CL:9807

Atrophin-like, and c4 zinc finger in nuclear hormone receptors

3 of 6

2.98

2.87

5.76e-06

CL:20400

Mixed, incl. Limb expression 1, and Retina layer formation

3 of 10

2.75

2.66

1.25e-05

CL:6889

Mixed, incl. FERM domain-containing protein 6-like, and WWC, C2 domain

3 of 12

2.67

2.56

1.82e-05

CL:20403

Limb expression 1, and Retina layer formation

2 of 5

2.88

1.61

0.0012

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04392

Hippo signaling pathway - multiple species

4 of 78

1.99

2.33

1.41e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8943724

Regulation of PTEN gene transcription

3 of 68

1.92

1.03

0.0102

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098592

Cytoplasmic side of apical plasma membrane

3 of 5

3.05

2.77

9.20e-06

GOCC:0035003

Subapical complex

2 of 5

2.88

1.51

0.0018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03154

Atrophin-1 family

3 of 3

3.28

2.94

4.75e-06

PF14954

Limb expression 1

2 of 2

3.28

1.55

0.0016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047145

FERM domain-containing protein 6-like

3 of 3

3.28

2.67

1.53e-05

IPR002951

Atrophin-like

3 of 3

3.28

2.67

1.53e-05

IPR029270

Limb expression 1

2 of 2

3.28

1.49

0.0021

IPR018980

FERM, C-terminal PH-like domain

3 of 35

2.21

1.43

0.0020

IPR018979

FERM, N-terminal

3 of 34

2.22

1.43

0.0020

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01196

FERM C-terminal PH-like domain

3 of 35

2.21

1.66

0.00070

SM00295

Band 4.1 homologues

3 of 64

1.95

1.37

0.0020

SM01189

The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex PUBMED:10226007. The domain is usually found to the N terminus of a myb-like DNA binding domain SANT ...

2 of 11

2.54

1.26

0.0050

SM00717

SANT SWI3, ADA2, N-CoR and TFIIIB DNA-binding domains

2 of 44

1.93

0.69

0.0498

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