STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pthaminoacyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (192 aa)    
Predicted Functional Partners:
rplY
50S ribosomal protein L25/general stress protein Ctc; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
  
  
 0.879
ychF
Redox-regulated ATPase YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
 
  
 0.869
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
 
   
 0.869
prfB
Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
 
  
 0.713
mfd
Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
  
  
 0.713
guaA
Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.706
frr
Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.
 
  
 0.692
PcaB
3-carboxy-cis,cis-muconate cycloisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.685
fusA
Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
 
  
 0.670
pcaD
3-oxoadipate enol-lactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.657
Your Current Organism:
Rhodococcus hoagii
NCBI taxonomy Id: 43767
Other names: ATCC 14887 [[Nocardia restricta]], ATCC 25729 [[Rhodococcus equi]], ATCC 6939 [[Rhodococcus equi]], ATCC 7005 [[Corynebacterium hoagii]], Bacillus hoagii, CCUG 17758 [[Nocardia restricta]], CCUG 20991 [[Corynebacterium hoagii]], CCUG 892 [[Rhodococcus equi]], CIP 54.72 [[Rhodococcus equi]], CIP 81.17 [[Corynebacterium hoagii]], Corynebacterium (pyogenes) equi roseum, Corynebacterium hoagii, Corynebacterium magnusson-holth, Corynebacterium purulentus, Corynebacterium pyogenes (equi), DSM 20295 [[Corynebacterium hoagii]], DSM 20307 [[Rhodococcus equi]], DSM 43199 [[Nocardia restricta]], HAMBI 2061 [[Rhodococcus equi]], IFO 14956 [[Rhodococcus equi]], JCM 3209 [[Rhodococcus equi]], JCM 3223 [[Nocardia restricta]], LMG 18452 [[Rhodococcus equi]], LMG 7335 [[Nocardia restricta]], LMG:18452 [[Rhodococcus equi]], LMG:7335 [[Nocardia restricta]], Mycobacterium equi, Mycobacterium restrictum, NBRC 101255 [[Rhodococcus equi]], NBRC 103062 [[Corynebacterium hoagii]], NBRC 14956 [[Rhodococcus equi]], NCTC 10673 [[Corynebacterium hoagii]], NRRL B-16538 [[Rhodococcus equi]], Nocardia restricta, Prescottella equi, Prescottia equi, Proactinomyces restrictus, R. hoagii, Rhodococcus equi, VKM Ac-953 [[Rhodococcus equi]]
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