node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
H3K480_9FIRM | H3K9Q2_9FIRM | GCA_900128435_02022 | GCA_900128435_00985 | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | 0.575 |
H3K9Q2_9FIRM | H3K480_9FIRM | GCA_900128435_00985 | GCA_900128435_02022 | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.575 |
H3K9Q2_9FIRM | H3K9R4_9FIRM | GCA_900128435_00985 | GCA_900128435_00984 | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | Radical SAM protein, TatD family-associated. | 0.661 |
H3K9Q2_9FIRM | ThiD | GCA_900128435_00985 | GCA_900128435_00680 | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | Phosphomethylpyrimidine kinase. | 0.905 |
H3K9Q2_9FIRM | ThiD-2 | GCA_900128435_00985 | GCA_900128435_01190 | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | Phosphomethylpyrimidine kinase. | 0.529 |
H3K9Q2_9FIRM | ilvD | GCA_900128435_00985 | GCA_900128435_00986 | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.800 |
H3K9Q2_9FIRM | leuA | GCA_900128435_00985 | GCA_900128435_00987 | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.440 |
H3K9Q2_9FIRM | pdxS | GCA_900128435_00985 | GCA_900128435_01042 | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | Pyridoxal 5'-phosphate synthase subunit PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | 0.914 |
H3K9Q2_9FIRM | pdxT | GCA_900128435_00985 | GCA_900128435_01043 | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | Pyridoxal 5'-phosphate synthase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | 0.917 |
H3K9Q2_9FIRM | thiC | GCA_900128435_00985 | GCA_900128435_01453 | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.499 |
H3K9Q2_9FIRM | thiE | GCA_900128435_00985 | GCA_900128435_01586 | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.499 |
H3K9R4_9FIRM | H3K9Q2_9FIRM | GCA_900128435_00984 | GCA_900128435_00985 | Radical SAM protein, TatD family-associated. | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | 0.661 |
H3K9R4_9FIRM | ilvD | GCA_900128435_00984 | GCA_900128435_00986 | Radical SAM protein, TatD family-associated. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.475 |
ThiD | H3K9Q2_9FIRM | GCA_900128435_00680 | GCA_900128435_00985 | Phosphomethylpyrimidine kinase. | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | 0.905 |
ThiD | ThiD-2 | GCA_900128435_00680 | GCA_900128435_01190 | Phosphomethylpyrimidine kinase. | Phosphomethylpyrimidine kinase. | 0.596 |
ThiD | pdxS | GCA_900128435_00680 | GCA_900128435_01042 | Phosphomethylpyrimidine kinase. | Pyridoxal 5'-phosphate synthase subunit PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | 0.911 |
ThiD | pdxT | GCA_900128435_00680 | GCA_900128435_01043 | Phosphomethylpyrimidine kinase. | Pyridoxal 5'-phosphate synthase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | 0.909 |
ThiD | thiC | GCA_900128435_00680 | GCA_900128435_01453 | Phosphomethylpyrimidine kinase. | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.790 |
ThiD | thiE | GCA_900128435_00680 | GCA_900128435_01586 | Phosphomethylpyrimidine kinase. | Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.991 |
ThiD-2 | H3K9Q2_9FIRM | GCA_900128435_01190 | GCA_900128435_00985 | Phosphomethylpyrimidine kinase. | Pyridoxal kinase; Belongs to the pyridoxine kinase family. | 0.529 |