AZC_3566 protein (Azorhizobium caulinodans) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AZC_3566

Hypothetical conserved protein; With GGDEF domain. (437 aa)

Predicted Functional Partners:

AZC_3902

0.970

AZC_2507

0.924

luxR-4

0.898

AZC_1222

0.892

AZC_0914

0.860

AZC_0617

0.859

AZC_3085

0.834

phoB

0.638

AZC_3098

0.632

AZC_2447

0.581

Your Current Organism:

Azorhizobium caulinodans

NCBI taxonomy Id: 438753
Other names: A. caulinodans ORS 571, Azorhizobium caulinodans ORS 571, Azorhizobium caulinodans str. ORS 571, Azorhizobium caulinodans strain ORS 571, Rhizobium sp. ORS 571

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AZC_0617	AZC_0914	AZC_0617	AZC_0914	Two-component system response regulator.	Metal-dependent phosphohydrolase; HD subdomain.	0.699
AZC_0617	AZC_3085	AZC_0617	AZC_3085	Two-component system response regulator.	Hypothetical 80.5 kDa protein in ntrC 5'region.	0.775
AZC_0617	AZC_3098	AZC_0617	AZC_3098	Two-component system response regulator.	Putative ATPase.	0.672
AZC_0617	AZC_3566	AZC_0617	AZC_3566	Two-component system response regulator.	Hypothetical conserved protein; With GGDEF domain.	0.859
AZC_0914	AZC_0617	AZC_0914	AZC_0617	Metal-dependent phosphohydrolase; HD subdomain.	Two-component system response regulator.	0.699
AZC_0914	AZC_1222	AZC_0914	AZC_1222	Metal-dependent phosphohydrolase; HD subdomain.	Hypothetical protein; EAL domain.	0.490
AZC_0914	AZC_2507	AZC_0914	AZC_2507	Metal-dependent phosphohydrolase; HD subdomain.	EAL domain protein.	0.586
AZC_0914	AZC_3085	AZC_0914	AZC_3085	Metal-dependent phosphohydrolase; HD subdomain.	Hypothetical 80.5 kDa protein in ntrC 5'region.	0.817
AZC_0914	AZC_3098	AZC_0914	AZC_3098	Metal-dependent phosphohydrolase; HD subdomain.	Putative ATPase.	0.655
AZC_0914	AZC_3566	AZC_0914	AZC_3566	Metal-dependent phosphohydrolase; HD subdomain.	Hypothetical conserved protein; With GGDEF domain.	0.860
AZC_0914	AZC_3902	AZC_0914	AZC_3902	Metal-dependent phosphohydrolase; HD subdomain.	Putative cylclic diguanylate phosphodiesterase; EAL precursor.	0.513
AZC_0914	luxR-4	AZC_0914	AZC_4108	Metal-dependent phosphohydrolase; HD subdomain.	Two component transcriptional regulator; LuxR family.	0.903
AZC_0914	phoB	AZC_0914	AZC_4032	Metal-dependent phosphohydrolase; HD subdomain.	Phosphate regulon transcriptional regulatory protein.	0.561
AZC_1222	AZC_0914	AZC_1222	AZC_0914	Hypothetical protein; EAL domain.	Metal-dependent phosphohydrolase; HD subdomain.	0.490
AZC_1222	AZC_3085	AZC_1222	AZC_3085	Hypothetical protein; EAL domain.	Hypothetical 80.5 kDa protein in ntrC 5'region.	0.512
AZC_1222	AZC_3098	AZC_1222	AZC_3098	Hypothetical protein; EAL domain.	Putative ATPase.	0.593
AZC_1222	AZC_3566	AZC_1222	AZC_3566	Hypothetical protein; EAL domain.	Hypothetical conserved protein; With GGDEF domain.	0.892
AZC_2447	AZC_3085	AZC_2447	AZC_3085	ABC transporter substrate binding protein.	Hypothetical 80.5 kDa protein in ntrC 5'region.	0.402
AZC_2447	AZC_3566	AZC_2447	AZC_3566	ABC transporter substrate binding protein.	Hypothetical conserved protein; With GGDEF domain.	0.581
AZC_2447	AZC_3902	AZC_2447	AZC_3902	ABC transporter substrate binding protein.	Putative cylclic diguanylate phosphodiesterase; EAL precursor.	0.692

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.883

expected number of edges:

11

PPI enrichment p-value:

3.33e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006473

Protein acetylation

4 of 72

1.81

1.24

0.0031

GO:0017196

N-terminal peptidyl-methionine acetylation

2 of 5

2.67

0.78

0.0393

GO:0002031

G protein-coupled receptor internalization

2 of 5

2.67

0.78

0.0393

GO:0007191

Adenylate cyclase-activating dopamine receptor signaling pathway

2 of 7

2.52

0.77

0.0393

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001664

G protein-coupled receptor binding

4 of 109

1.63

1.12

0.0043

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031248

Protein acetyltransferase complex

5 of 54

2.03

2.84

9.75e-07

GO:0070461

SAGA-type complex

3 of 16

2.34

1.97

0.00019

GO:0031415

NatA complex

2 of 3

2.89

1.54

0.0016

GO:0140672

ATAC complex

2 of 6

2.59

1.36

0.0033

GO:0005834

Heterotrimeric G-protein complex

2 of 21

2.04

0.92

0.0188

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19863

N-terminal protein amino acid acetylation

3 of 7

2.7

2.1

0.00014

CL:5844

SAGA complex, and SWIRM domain

2 of 6

2.59

0.99

0.0156

CL:16972

Mixed, incl. Amine ligand-binding receptors, and Heterotrimeric G-protein complex

3 of 68

1.71

0.9

0.0163

CL:17078

Mixed, incl. G protein-coupled receptor kinase activity, and Arrestin

2 of 14

2.22

0.89

0.0222

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5635838

Activation of SMO

2 of 8

2.46

0.72

0.0484

MAP-418555

G alpha (s) signalling events

3 of 89

1.59

0.66

0.0484

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031248

Protein acetyltransferase complex

5 of 48

2.08

2.97

6.08e-07

GOCC:0070461

SAGA-type complex

3 of 14

2.4

2.05

0.00014

GOCC:0031415

NatA complex

2 of 4

2.76

1.46

0.0022

GOCC:0005834

Heterotrimeric G-protein complex

2 of 11

2.32

1.14

0.0077

GOCC:1902494

Catalytic complex

7 of 848

0.98

0.87

0.00050

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00339

Arrestin (or S-antigen), N-terminal domain

2 of 7

2.52

0.81

0.0344

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR021183

N-terminal acetyltransferase A, auxiliary subunit

2 of 2

3.06

0.96

0.0187

IPR017864

Arrestin, conserved site

2 of 3

2.89

0.96

0.0187

IPR014753

Arrestin, N-terminal

2 of 3

2.89

0.96

0.0187

IPR000698

Arrestin

2 of 3

2.89

0.96

0.0187

IPR000367

G-protein alpha subunit, group S

2 of 2

3.06

0.96

0.0187

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01017

Arrestin (or S-antigen), C-terminal domain

2 of 7

2.52

1.0

0.0150

SM00275

G protein alpha subunit

2 of 15

2.19

0.84

0.0282

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