STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rpoNRNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of the nitrogen fixation genes. (514 aa)    
Predicted Functional Partners:
nifA
Nif-specific regulatory protein; Required for activation of most nif operons, which are directly involved in nitrogen fixation.
 
   
 0.967
ntrC
Nitrogen assimilation regulatory protein ntrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
 
  
 0.953
rpoA
DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.934
rpoC
RNA polymerase I subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 
 0.921
rpoB
DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.907
rpoZ
RNA polymerase omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
   
 
 0.887
fis
Transcriptional regulator; Fis family.
 
  
 0.869
AZC_3213
Sigma-54 factor; Interaction region.
 
   
 0.840
hoxA
HoxA protein.
 
  
 0.831
ntrX
Nitrogen assimilation regulatory protein ntrX; Member of the two-component regulatory system NtrY/NtrX involved in the activation of nitrogen assimilatory genes such as GlnA. NtrX is probably phosphorylated by NtrY and interacts with sigma-54.
 
  
 0.831
Your Current Organism:
Azorhizobium caulinodans
NCBI taxonomy Id: 438753
Other names: A. caulinodans ORS 571, Azorhizobium caulinodans ORS 571, Azorhizobium caulinodans str. ORS 571, Azorhizobium caulinodans strain ORS 571, Rhizobium sp. ORS 571
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