STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fixJTranscriptional regulatory protein fixJ; FixJ, when activated by FixL, induces the expression of both nifA, required for activation of classical nif and fix genes, and fixK, required for fixN activation. (211 aa)    
Predicted Functional Partners:
fixL
Sensor protein fixL; Putative oxygen sensor; modulates the activity of FixJ, a transcriptional activator of nitrogen fixation fixK gene. FixL probably acts as a kinase that phosphorylates FixJ.
 0.999
AZC_1360
Sensor protein.
 0.979
AZC_3292
Histidine kinase A; ATP-binding region.
 0.974
fixK
Nitrogen fixation regulation protein; FixK is a protein that regulates nitrogen fixation genes both positively and negatively. FixK is a positive regulator of NifA expression. FixK may bind DNA at the FNR consensus binding site.
 
   
 0.910
nifA
Nif-specific regulatory protein; Required for activation of most nif operons, which are directly involved in nitrogen fixation.
 
  
 0.801
ntrB
Signal transduction histidine kinase; NtrB/NtrY.
 
 0.794
AZC_0193
Putative sensor nodulation protein.
 
 0.792
AZC_4656
Response regulator receiver.
 
    
0.727
AZC_4365
Response regulator receiver.
  
     0.582
AZC_3923
Response regulator receiver; ATP-binding region, histidine kinase A, N-terminal precursor.
  
 
 0.552
Your Current Organism:
Azorhizobium caulinodans
NCBI taxonomy Id: 438753
Other names: A. caulinodans ORS 571, Azorhizobium caulinodans ORS 571, Azorhizobium caulinodans str. ORS 571, Azorhizobium caulinodans strain ORS 571, Rhizobium sp. ORS 571
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