node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHG53929.1 | SHH43565.1 | SAMN05443636_0568 | SAMN05443636_2575 | DNA polymerase I. | Replication factor C small subunit. | 0.867 |
SHG53929.1 | fen | SAMN05443636_0568 | SAMN05443636_2892 | DNA polymerase I. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.981 |
SHG53929.1 | lig | SAMN05443636_0568 | SAMN05443636_2180 | DNA polymerase I. | DNA ligase-1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.844 |
SHG53929.1 | pcn | SAMN05443636_0568 | SAMN05443636_2627 | DNA polymerase I. | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.999 |
SHG53929.1 | polB | SAMN05443636_0568 | SAMN05443636_2547 | DNA polymerase I. | DNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.999 |
SHG53929.1 | priL | SAMN05443636_0568 | SAMN05443636_2581 | DNA polymerase I. | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.991 |
SHG53929.1 | priS | SAMN05443636_0568 | SAMN05443636_2480 | DNA polymerase I. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.990 |
SHG53929.1 | rfcS | SAMN05443636_0568 | SAMN05443636_1896 | DNA polymerase I. | Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.858 |
SHH43565.1 | SHG53929.1 | SAMN05443636_2575 | SAMN05443636_0568 | Replication factor C small subunit. | DNA polymerase I. | 0.867 |
SHH43565.1 | SHH43599.1 | SAMN05443636_2575 | SAMN05443636_2576 | Replication factor C small subunit. | Phosphatidylserine decarboxylase. | 0.816 |
SHH43565.1 | fen | SAMN05443636_2575 | SAMN05443636_2892 | Replication factor C small subunit. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.831 |
SHH43565.1 | lig | SAMN05443636_2575 | SAMN05443636_2180 | Replication factor C small subunit. | DNA ligase-1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.748 |
SHH43565.1 | pcn | SAMN05443636_2575 | SAMN05443636_2627 | Replication factor C small subunit. | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.970 |
SHH43565.1 | polB | SAMN05443636_2575 | SAMN05443636_2547 | Replication factor C small subunit. | DNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.719 |
SHH43565.1 | priL | SAMN05443636_2575 | SAMN05443636_2581 | Replication factor C small subunit. | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.812 |
SHH43565.1 | priS | SAMN05443636_2575 | SAMN05443636_2480 | Replication factor C small subunit. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.832 |
SHH43565.1 | rfcS | SAMN05443636_2575 | SAMN05443636_1896 | Replication factor C small subunit. | Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.927 |
SHH43565.1 | tmk | SAMN05443636_2575 | SAMN05443636_1021 | Replication factor C small subunit. | Thymidylate kinase. | 0.725 |
SHH43599.1 | SHH43565.1 | SAMN05443636_2576 | SAMN05443636_2575 | Phosphatidylserine decarboxylase. | Replication factor C small subunit. | 0.816 |
fen | SHG53929.1 | SAMN05443636_2892 | SAMN05443636_0568 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | DNA polymerase I. | 0.981 |