| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Bsel_0486 | Bsel_1422 | Bsel_0486 | Bsel_1422 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.509 |
| Bsel_0486 | Bsel_2898 | Bsel_0486 | Bsel_2898 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: periplasmic binding protein; KEGG: dol:Dole_2060 periplasmic binding protein. | 0.470 |
| Bsel_0486 | icmF | Bsel_0486 | Bsel_3186 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methylmalonyl-CoA mutase, large subunit; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. | 0.498 |
| Bsel_1422 | Bsel_0486 | Bsel_1422 | Bsel_0486 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.509 |
| Bsel_1422 | Bsel_2190 | Bsel_1422 | Bsel_2190 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.456 |
| Bsel_1422 | Bsel_2898 | Bsel_1422 | Bsel_2898 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | PFAM: periplasmic binding protein; KEGG: dol:Dole_2060 periplasmic binding protein. | 0.502 |
| Bsel_1422 | Bsel_2899 | Bsel_1422 | Bsel_2899 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | PFAM: transport system permease protein; KEGG: mlo:mll1150 permease protein of ABC transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | 0.504 |
| Bsel_1422 | icmF | Bsel_1422 | Bsel_3186 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | methylmalonyl-CoA mutase, large subunit; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. | 0.500 |
| Bsel_2190 | Bsel_1422 | Bsel_2190 | Bsel_1422 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.456 |
| Bsel_2190 | Bsel_2898 | Bsel_2190 | Bsel_2898 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: periplasmic binding protein; KEGG: dol:Dole_2060 periplasmic binding protein. | 0.499 |
| Bsel_2818 | Bsel_2819 | Bsel_2818 | Bsel_2819 | PFAM: transport system permease protein; KEGG: asu:Asuc_1823 transport system permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | PFAM: transport system permease protein; KEGG: msu:MS0793 BtuC protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | 0.988 |
| Bsel_2818 | Bsel_2820 | Bsel_2818 | Bsel_2820 | PFAM: transport system permease protein; KEGG: asu:Asuc_1823 transport system permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | KEGG: msu:MS0794 FepC protein; PFAM: ABC transporter related; SMART: AAA ATPase. | 0.991 |
| Bsel_2818 | Bsel_2821 | Bsel_2818 | Bsel_2821 | PFAM: transport system permease protein; KEGG: asu:Asuc_1823 transport system permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | PFAM: periplasmic binding protein; KEGG: bmc:BAbS19_II05320 periplasmic binding protein. | 0.986 |
| Bsel_2818 | Bsel_2898 | Bsel_2818 | Bsel_2898 | PFAM: transport system permease protein; KEGG: asu:Asuc_1823 transport system permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | PFAM: periplasmic binding protein; KEGG: dol:Dole_2060 periplasmic binding protein. | 0.694 |
| Bsel_2818 | Bsel_2899 | Bsel_2818 | Bsel_2899 | PFAM: transport system permease protein; KEGG: asu:Asuc_1823 transport system permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | PFAM: transport system permease protein; KEGG: mlo:mll1150 permease protein of ABC transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | 0.586 |
| Bsel_2818 | Bsel_2900 | Bsel_2818 | Bsel_2900 | PFAM: transport system permease protein; KEGG: asu:Asuc_1823 transport system permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | Protein of unknown function DUF105; KEGG: sat:SYN_01426 ABC-type cobalamin/Fe3+-siderophore transport system, ATPase component; PFAM: protein of unknown function DUF105; ABC transporter related; SMART: AAA ATPase. | 0.526 |
| Bsel_2819 | Bsel_2818 | Bsel_2819 | Bsel_2818 | PFAM: transport system permease protein; KEGG: msu:MS0793 BtuC protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | PFAM: transport system permease protein; KEGG: asu:Asuc_1823 transport system permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | 0.988 |
| Bsel_2819 | Bsel_2820 | Bsel_2819 | Bsel_2820 | PFAM: transport system permease protein; KEGG: msu:MS0793 BtuC protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | KEGG: msu:MS0794 FepC protein; PFAM: ABC transporter related; SMART: AAA ATPase. | 0.995 |
| Bsel_2819 | Bsel_2821 | Bsel_2819 | Bsel_2821 | PFAM: transport system permease protein; KEGG: msu:MS0793 BtuC protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | PFAM: periplasmic binding protein; KEGG: bmc:BAbS19_II05320 periplasmic binding protein. | 0.986 |
| Bsel_2819 | Bsel_2898 | Bsel_2819 | Bsel_2898 | PFAM: transport system permease protein; KEGG: msu:MS0793 BtuC protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | PFAM: periplasmic binding protein; KEGG: dol:Dole_2060 periplasmic binding protein. | 0.599 |