STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
sucA2-oxoglutarate dehydrogenase, E1 subunit; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (1001 aa)    
Predicted Functional Partners:
Oant_0934
2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.999
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.996
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.986
Oant_0938
TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: bms:BR1918 dihydrolipoamide dehydrogenase.
 
 0.981
Oant_1992
TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bmb:BruAb1_1204 isocitrate dehydrogenase, NADP-dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
   
 
 0.979
Oant_2061
Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.972
Oant_2063
TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; KEGG: bms:BR1126 pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase.
 
 0.972
Oant_3554
TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; KEGG: bms:BRA0527 2-oxoisovalerate dehydrogenase, E3 component, lipoamide dehydrogenase.
  
 0.968
Oant_3553
PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: bms:BRA0526 2-oxoisovalerate dehydrogenase E2 component, dihydrolipoamide acetyltransferase.
 
 0.965
Oant_4115
PFAM: alpha/beta hydrolase fold; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; KEGG: bmb:BruAb2_1023 dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase.
  
 0.964
Your Current Organism:
Ochrobactrum anthropi
NCBI taxonomy Id: 439375
Other names: O. anthropi ATCC 49188, Ochrobactrum anthropi ATCC 49188, Ochrobactrum anthropi DSM 6882, Ochrobactrum anthropi LMG 3331, Ochrobactrum anthropi str. ATCC 49188, Ochrobactrum anthropi strain ATCC 49188
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.