| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Oant_0188 | Oant_0197 | Oant_0188 | Oant_0197 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.606 |
| Oant_0188 | Oant_1896 | Oant_0188 | Oant_1896 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: bme:BMEI0712 cbiG protein / precorrin-3B C17-methyltransferase. | 0.700 |
| Oant_0188 | Oant_2152 | Oant_0188 | Oant_2152 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | PFAM: nitroreductase; KEGG: bmb:BruAb1_1074 nitroreductase family protein. | 0.526 |
| Oant_0188 | ribB | Oant_0188 | Oant_0540 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.423 |
| Oant_0197 | Oant_0188 | Oant_0197 | Oant_0188 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.606 |
| Oant_0197 | Oant_1896 | Oant_0197 | Oant_1896 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: bme:BMEI0712 cbiG protein / precorrin-3B C17-methyltransferase. | 0.457 |
| Oant_0197 | Oant_2152 | Oant_0197 | Oant_2152 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: nitroreductase; KEGG: bmb:BruAb1_1074 nitroreductase family protein. | 0.523 |
| Oant_0373 | Oant_2152 | Oant_0373 | Oant_2152 | PFAM: AMP-dependent synthetase and ligase; KEGG: bme:BMEI1632 acyl-CoA synthase. | PFAM: nitroreductase; KEGG: bmb:BruAb1_1074 nitroreductase family protein. | 0.657 |
| Oant_0409 | Oant_1824 | Oant_0409 | Oant_1824 | Integral membrane sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: bms:BR0316 sensor histidine kinase/response regulator. | PFAM: ABC transporter related; ABC-2 type transporter; SMART: AAA ATPase; KEGG: bms:BR1350 ABC transporter, ATP binding/permease protein. | 0.486 |
| Oant_0409 | Oant_2152 | Oant_0409 | Oant_2152 | Integral membrane sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: bms:BR0316 sensor histidine kinase/response regulator. | PFAM: nitroreductase; KEGG: bmb:BruAb1_1074 nitroreductase family protein. | 0.544 |
| Oant_0409 | ribB | Oant_0409 | Oant_0540 | Integral membrane sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: bms:BR0316 sensor histidine kinase/response regulator. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.628 |
| Oant_1824 | Oant_0409 | Oant_1824 | Oant_0409 | PFAM: ABC transporter related; ABC-2 type transporter; SMART: AAA ATPase; KEGG: bms:BR1350 ABC transporter, ATP binding/permease protein. | Integral membrane sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: bms:BR0316 sensor histidine kinase/response regulator. | 0.486 |
| Oant_1824 | Oant_2152 | Oant_1824 | Oant_2152 | PFAM: ABC transporter related; ABC-2 type transporter; SMART: AAA ATPase; KEGG: bms:BR1350 ABC transporter, ATP binding/permease protein. | PFAM: nitroreductase; KEGG: bmb:BruAb1_1074 nitroreductase family protein. | 0.787 |
| Oant_1896 | Oant_0188 | Oant_1896 | Oant_0188 | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: bme:BMEI0712 cbiG protein / precorrin-3B C17-methyltransferase. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.700 |
| Oant_1896 | Oant_0197 | Oant_1896 | Oant_0197 | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: bme:BMEI0712 cbiG protein / precorrin-3B C17-methyltransferase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.457 |
| Oant_1896 | Oant_2152 | Oant_1896 | Oant_2152 | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: bme:BMEI0712 cbiG protein / precorrin-3B C17-methyltransferase. | PFAM: nitroreductase; KEGG: bmb:BruAb1_1074 nitroreductase family protein. | 0.528 |
| Oant_1896 | ribB | Oant_1896 | Oant_0540 | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: bme:BMEI0712 cbiG protein / precorrin-3B C17-methyltransferase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.431 |
| Oant_2151 | Oant_2152 | Oant_2151 | Oant_2152 | KEGG: bmb:BruAb1_1073 hypothetical protein. | PFAM: nitroreductase; KEGG: bmb:BruAb1_1074 nitroreductase family protein. | 0.725 |
| Oant_2151 | Oant_2153 | Oant_2151 | Oant_2153 | KEGG: bmb:BruAb1_1073 hypothetical protein. | KEGG: bmb:BruAb1_1075 hypothetical protein. | 0.495 |
| Oant_2151 | ribB | Oant_2151 | Oant_0540 | KEGG: bmb:BruAb1_1073 hypothetical protein. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.418 |