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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthDNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa)    
Predicted Functional Partners:
Aboo_0823
TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; KEGG: tvo:TVN0046 exonuclease III; PFAM: Endonuclease/exonuclease/phosphatase.
 
 0.976
nfi
methylated-DNA/protein-cysteine methyltransferase; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
     
 0.710
Aboo_0637
KEGG: tvo:TVN0157 endonuclease IV; PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease family 2.
  
 
 0.618
Aboo_0955
DNA helicase; KEGG: mka:MK0070 superfamily I DNA/RNA helicase; TIGRFAM: DNA helicase; SMART: DEAD-like helicase.
 
  
 
 0.589
Aboo_0367
KEGG: tac:Ta0336 hypothetical protein.
       0.551
Aboo_0314
PFAM: peptidase M50; KEGG: tac:Ta1274 sterol-regulatory element-binding proteins intramembrane protease related protein.
 
 
 
 0.548
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 
 0.479
Aboo_0400
ERCC4 domain protein; KEGG: afu:AF2418 DNA repair protein, putative; PFAM: ERCC4 domain protein; helix-hairpin-helix motif; SMART: ERCC4 domain protein; Helix-hairpin-helix DNA-binding class 1.
  
 
 
 0.477
Aboo_0706
KEGG: tsi:TSIB_2019 pyrophosphorylase; TIGRFAM: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
 0.472
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 
 0.452
Your Current Organism:
Aciduliprofundum boonei
NCBI taxonomy Id: 439481
Other names: A. boonei T469, Aciduliprofundum boonei DSM 19572, Aciduliprofundum boonei T469, Aciduliprofundum boonei str. T469, Aciduliprofundum boonei strain T469
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