STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fhsKEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. (536 aa)    
Predicted Functional Partners:
folD
Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
   
 0.990
Aboo_0635
KEGG: tvo:TVN0796 glycine hydroxymethyltransferase; PFAM: glycine hydroxymethyltransferase.
  
 0.981
Aboo_0850
SMART: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: chy:CHY_1078 bifunctional purine biosynthesis protein PurH; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein.
  
 0.968
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.955
Aboo_0482
KEGG: mba:Mbar_A2317 phosphoribosylglycinamide formyltransferase; TIGRFAM: phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein.
  
 0.953
Aboo_1135
TIGRFAM: glutamate formiminotransferase; KEGG: hypothetical protein; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein; Formiminotransferase-cyclodeaminase.
    
 0.942
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
  
 0.939
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
  0.903
Aboo_0686
PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: tte:TTE2131 NADH:flavin oxidoreductase.
  
  
 0.716
purC
KEGG: tac:Ta0309 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase.
  
 
 0.684
Your Current Organism:
Aciduliprofundum boonei
NCBI taxonomy Id: 439481
Other names: A. boonei T469, Aciduliprofundum boonei DSM 19572, Aciduliprofundum boonei T469, Aciduliprofundum boonei str. T469, Aciduliprofundum boonei strain T469
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