STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Aboo_0823TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; KEGG: tvo:TVN0046 exonuclease III; PFAM: Endonuclease/exonuclease/phosphatase. (255 aa)    
Predicted Functional Partners:
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 0.999
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
 
 0.999
nth
DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
 0.976
Aboo_0353
HhH-GPD family protein; KEGG: tko:TK0345 3-methyladenine DNA glycosylase; PFAM: HhH-GPD family protein; SMART: HhH-GPD family protein.
  
 0.901
pcn
Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
 0.901
Aboo_0637
KEGG: tvo:TVN0157 endonuclease IV; PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease family 2.
   
 
 0.838
Aboo_1295
KEGG: sat:SYN_02040 putative cytoplasmic protein.
  
 0.769
nfi
methylated-DNA/protein-cysteine methyltransferase; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
     
 0.677
Aboo_0400
ERCC4 domain protein; KEGG: afu:AF2418 DNA repair protein, putative; PFAM: ERCC4 domain protein; helix-hairpin-helix motif; SMART: ERCC4 domain protein; Helix-hairpin-helix DNA-binding class 1.
   
 
 0.657
Aboo_0653
Like-Sm ribonucleoprotein core; KEGG: tvo:TVN1075 small nuclear ribonucleoprotein (snRNP)-like protein; PFAM: Like-Sm ribonucleoprotein core; SMART: Sm-family ribonucleoprotein.
   
 0.654
Your Current Organism:
Aciduliprofundum boonei
NCBI taxonomy Id: 439481
Other names: A. boonei T469, Aciduliprofundum boonei DSM 19572, Aciduliprofundum boonei T469, Aciduliprofundum boonei str. T469, Aciduliprofundum boonei strain T469
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