STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Aboo_1036KEGG: nth:Nther_0897 hypothetical protein. (890 aa)    
Predicted Functional Partners:
Aboo_1037
PFAM: metallophosphoesterase; KEGG: nth:Nther_0896 metallophosphoesterase.
 
 0.985
Aboo_0854
PFAM: metallophosphoesterase; KEGG: mth:MTH541 Rad32 related protein.
 
 0.882
Aboo_1035
Hypothetical protein; KEGG: apv:Apar_0842 ATP-dependent metalloprotease FtsH.
       0.723
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 0.691
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.654
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
 0.612
Aboo_1039
KEGG: sto:ST1161 hypothetical protein.
     
 0.555
Aboo_1038
KEGG: cbi:CLJ_B2383 hypothetical protein.
       0.543
Aboo_0196
DEAD_2 domain protein; KEGG: tvo:TVN0013 RAD3-related DNA helicase; PFAM: DEAD_2 domain protein; SMART: helicase c2; Helicase-like, DEXD box c2 type; DEAD-like helicase.
 
 
 0.523
Aboo_0797
PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: pto:PTO0673 single-stranded DNA-binding protein.
  
 0.504
Your Current Organism:
Aciduliprofundum boonei
NCBI taxonomy Id: 439481
Other names: A. boonei T469, Aciduliprofundum boonei DSM 19572, Aciduliprofundum boonei T469, Aciduliprofundum boonei str. T469, Aciduliprofundum boonei strain T469
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