STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Aboo_1103KEGG: afu:AF1458 Hef nuclease; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; ERCC4 domain protein; helix-hairpin-helix motif; SMART: DEAD-like helicase; helicase domain protein; Helix-hairpin-helix DNA-binding class 1. (756 aa)    
Predicted Functional Partners:
rpl1
Ribosomal protein L1; Binds directly to 23S rRNA. Probably involved in E site tRNA release.
    
 0.794
Aboo_0400
ERCC4 domain protein; KEGG: afu:AF2418 DNA repair protein, putative; PFAM: ERCC4 domain protein; helix-hairpin-helix motif; SMART: ERCC4 domain protein; Helix-hairpin-helix DNA-binding class 1.
  
 
0.727
Aboo_1312
PFAM: Ribosomal protein L40e; KEGG: mka:MK0641 50S ribosomal protein L40e.
  
 
  0.721
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.671
Aboo_1104
PFAM: major facilitator superfamily MFS_1; KEGG: tga:TGAM_1161 permease, major facilitator superfamily.
       0.664
Aboo_0797
PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: pto:PTO0673 single-stranded DNA-binding protein.
   
 0.640
Aboo_1248
PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: pho:PH1893 replication factor A.
   
 0.640
Aboo_1488
PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: hwa:HQ2405A replication factor A.
   
 0.640
radB
DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.
  
 
 0.565
Aboo_1102
PFAM: protein of unknown function DUF77; KEGG: hypothetical protein.
       0.560
Your Current Organism:
Aciduliprofundum boonei
NCBI taxonomy Id: 439481
Other names: A. boonei T469, Aciduliprofundum boonei DSM 19572, Aciduliprofundum boonei T469, Aciduliprofundum boonei str. T469, Aciduliprofundum boonei strain T469
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