prpE protein (Pelagibacter sp. HTCC7211) - STRING interaction network

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prpE

propionate--CoA ligase; [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (632 aa)

Predicted Functional Partners:

fadB

0.963

prpC

0.920

tme

0.907

mmsA

0.838

acsA

0.817

yhdH

0.793

EDZ60842.1

0.781

mmgC

0.778

mmsB_1

0.715

glcB

0.641

Your Current Organism:

Pelagibacter sp. HTCC7211

NCBI taxonomy Id: 439493
Other names: C. Pelagibacter sp. HTCC7211, Candidatus Pelagibacter sp. HTCC7211

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDZ60842.1	acsA	PB7211_1165	PB7211_371	[C] COG1012 NAD-dependent aldehyde dehydrogenases.	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.838
EDZ60842.1	fadB	PB7211_1165	PB7211_182	[C] COG1012 NAD-dependent aldehyde dehydrogenases.	3-hydroxyacyl-CoA dehydrogenase; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.822
EDZ60842.1	mmsA	PB7211_1165	PB7211_898	[C] COG1012 NAD-dependent aldehyde dehydrogenases.	Methylmalonate-semialdehyde dehydrogenase; [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase.	0.812
EDZ60842.1	mmsB_1	PB7211_1165	PB7211_947	[C] COG1012 NAD-dependent aldehyde dehydrogenases.	[G] COG0362 6-phosphogluconate dehydrogenase.	0.800
EDZ60842.1	prpC	PB7211_1165	PB7211_318	[C] COG1012 NAD-dependent aldehyde dehydrogenases.	[C] COG0372 Citrate synthase; Belongs to the citrate synthase family.	0.801
EDZ60842.1	prpE	PB7211_1165	PB7211_25	[C] COG1012 NAD-dependent aldehyde dehydrogenases.	propionate--CoA ligase; [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.	0.781
EDZ60842.1	tme	PB7211_1165	PB7211_1186	[C] COG1012 NAD-dependent aldehyde dehydrogenases.	NADP-dependent malic enzyme; [C] COG0280 Phosphotransacetylase.	0.816
EDZ60842.1	yhdH	PB7211_1165	PB7211_1286	[C] COG1012 NAD-dependent aldehyde dehydrogenases.	Zinc-binding alcohol dehydrogenase; [Q] COG3321 Polyketide synthase modules and related proteins.	0.748
acsA	EDZ60842.1	PB7211_371	PB7211_1165	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	[C] COG1012 NAD-dependent aldehyde dehydrogenases.	0.838
acsA	fadB	PB7211_371	PB7211_182	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	3-hydroxyacyl-CoA dehydrogenase; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.963
acsA	glcB	PB7211_371	PB7211_627	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.	0.885
acsA	mmgC	PB7211_371	PB7211_270	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	[I] COG1960 Acyl-CoA dehydrogenases.	0.509
acsA	mmsA	PB7211_371	PB7211_898	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Methylmalonate-semialdehyde dehydrogenase; [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase.	0.838
acsA	mmsB_1	PB7211_371	PB7211_947	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	[G] COG0362 6-phosphogluconate dehydrogenase.	0.715
acsA	prpC	PB7211_371	PB7211_318	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	[C] COG0372 Citrate synthase; Belongs to the citrate synthase family.	0.920
acsA	prpE	PB7211_371	PB7211_25	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	propionate--CoA ligase; [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.	0.817
acsA	tme	PB7211_371	PB7211_1186	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	NADP-dependent malic enzyme; [C] COG0280 Phosphotransacetylase.	0.907
acsA	yhdH	PB7211_371	PB7211_1286	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Zinc-binding alcohol dehydrogenase; [Q] COG3321 Polyketide synthase modules and related proteins.	0.793
fadB	EDZ60842.1	PB7211_182	PB7211_1165	3-hydroxyacyl-CoA dehydrogenase; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	[C] COG1012 NAD-dependent aldehyde dehydrogenases.	0.822
fadB	acsA	PB7211_182	PB7211_371	3-hydroxyacyl-CoA dehydrogenase; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.963