STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
EDZ46935.1Thiamine pyrophosphate enzyme, central domain family; [E] COG3962 Acetolactate synthase; Belongs to the TPP enzyme family. (537 aa)    
Predicted Functional Partners:
ilvN
[E] COG0440 Acetolactate synthase, small (regulatory) subunit.
 
 0.968
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.874
EDZ45951.1
Tetratricopeptide repeat domain protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.
 
     0.860
EDZ48636.1
[S] COG4645 Uncharacterized protein conserved in bacteria.
 
     0.860
RBY4I_406
L-carnitine dehydratase/bile acid-inducible protein F; [C] COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; Belongs to the CoA-transferase III family.
  
 
  0.816
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.772
EDZ48195.1
Conserved hypothetical protein; [Q] COG3509 Poly(3-hydroxybutyrate) depolymerase.
  
     0.753
EDZ47453.1
Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme.
  
 0.735
RBY4I_385
Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme.
  
 0.735
RBY4I_301
Glucans biosynthesis glucosyltransferase H; [M] COG2943 Membrane glycosyltransferase.
 
     0.734
Your Current Organism:
Rhodobacterales bacterium Y4I
NCBI taxonomy Id: 439496
Other names: R. bacterium Y4I
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