| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EDZ47359.1 | folD | RBY4I_2577 | RBY4I_2826 | Luciferase-like monooxygenase family; [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.928 |
| EDZ47359.1 | folD-2 | RBY4I_2577 | RBY4I_2964 | Luciferase-like monooxygenase family; [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.928 |
| EDZ47359.1 | gcvP_1 | RBY4I_2577 | RBY4I_2617 | Luciferase-like monooxygenase family; [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.420 |
| EDZ47359.1 | gcvP_2 | RBY4I_2577 | RBY4I_4056 | Luciferase-like monooxygenase family; [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins. | [E] COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain. | 0.420 |
| EDZ47359.1 | gcvT | RBY4I_2577 | RBY4I_1070 | Luciferase-like monooxygenase family; [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Glycine cleavage system T protein; [R] COG0354 Predicted aminomethyltransferase related to GcvT. | 0.685 |
| EDZ47359.1 | glyA_2 | RBY4I_2577 | RBY4I_3208 | Luciferase-like monooxygenase family; [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.907 |
| EDZ47359.1 | purD | RBY4I_2577 | RBY4I_1888 | Luciferase-like monooxygenase family; [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Phosphoribosylamine--glycine ligase; [I] COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit; Belongs to the GARS family. | 0.658 |
| EDZ47359.1 | purH | RBY4I_2577 | RBY4I_1730 | Luciferase-like monooxygenase family; [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Bifunctional purine biosynthesis protein PurH; [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.611 |
| EDZ47359.1 | purN | RBY4I_2577 | RBY4I_3597 | Luciferase-like monooxygenase family; [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.913 |
| EDZ48643.1 | folD | RBY4I_3866 | RBY4I_2826 | Hypothetical protein; [C] COG2218 Formylmethanofuran dehydrogenase subunit C; Conserved region in glutamate synthase family. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.453 |
| EDZ48643.1 | folD-2 | RBY4I_3866 | RBY4I_2964 | Hypothetical protein; [C] COG2218 Formylmethanofuran dehydrogenase subunit C; Conserved region in glutamate synthase family. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.453 |
| EDZ48643.1 | gcvP_1 | RBY4I_3866 | RBY4I_2617 | Hypothetical protein; [C] COG2218 Formylmethanofuran dehydrogenase subunit C; Conserved region in glutamate synthase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.918 |
| EDZ48643.1 | gcvP_2 | RBY4I_3866 | RBY4I_4056 | Hypothetical protein; [C] COG2218 Formylmethanofuran dehydrogenase subunit C; Conserved region in glutamate synthase family. | [E] COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain. | 0.918 |
| EDZ48643.1 | gcvT | RBY4I_3866 | RBY4I_1070 | Hypothetical protein; [C] COG2218 Formylmethanofuran dehydrogenase subunit C; Conserved region in glutamate synthase family. | Glycine cleavage system T protein; [R] COG0354 Predicted aminomethyltransferase related to GcvT. | 0.804 |
| EDZ48643.1 | glyA_2 | RBY4I_3866 | RBY4I_3208 | Hypothetical protein; [C] COG2218 Formylmethanofuran dehydrogenase subunit C; Conserved region in glutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.909 |
| EDZ48643.1 | purD | RBY4I_3866 | RBY4I_1888 | Hypothetical protein; [C] COG2218 Formylmethanofuran dehydrogenase subunit C; Conserved region in glutamate synthase family. | Phosphoribosylamine--glycine ligase; [I] COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit; Belongs to the GARS family. | 0.497 |
| EDZ48643.1 | purH | RBY4I_3866 | RBY4I_1730 | Hypothetical protein; [C] COG2218 Formylmethanofuran dehydrogenase subunit C; Conserved region in glutamate synthase family. | Bifunctional purine biosynthesis protein PurH; [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.886 |
| EDZ48643.1 | purN | RBY4I_3866 | RBY4I_3597 | Hypothetical protein; [C] COG2218 Formylmethanofuran dehydrogenase subunit C; Conserved region in glutamate synthase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.431 |
| folD | EDZ47359.1 | RBY4I_2826 | RBY4I_2577 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Luciferase-like monooxygenase family; [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins. | 0.928 |
| folD | EDZ48643.1 | RBY4I_2826 | RBY4I_3866 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Hypothetical protein; [C] COG2218 Formylmethanofuran dehydrogenase subunit C; Conserved region in glutamate synthase family. | 0.453 |
STRING v12.5 is now available!
