| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EDZ46372.1 | EDZ46409.1 | RBY4I_1586 | RBY4I_1623 | Conserved hypothetical protein; [M] COG0773 UDP-N-acetylmuramate-alanine ligase. | HemY domain protein; [H] COG3071 Uncharacterized enzyme of heme biosynthesis. | 0.886 |
| EDZ46372.1 | EDZ46805.1 | RBY4I_1586 | RBY4I_2022 | Conserved hypothetical protein; [M] COG0773 UDP-N-acetylmuramate-alanine ligase. | Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | 0.423 |
| EDZ46372.1 | EDZ48054.1 | RBY4I_1586 | RBY4I_3274 | Conserved hypothetical protein; [M] COG0773 UDP-N-acetylmuramate-alanine ligase. | [S] COG2350 Uncharacterized protein conserved in bacteria. | 0.588 |
| EDZ46372.1 | RBY4I_357 | RBY4I_1586 | RBY4I_357 | Conserved hypothetical protein; [M] COG0773 UDP-N-acetylmuramate-alanine ligase. | ubiquinol-Cytochrome c reductase, iron-sulfur subunit; [S] COG1673 Uncharacterized protein conserved in archaea. | 0.590 |
| EDZ46372.1 | gpsA | RBY4I_1586 | RBY4I_857 | Conserved hypothetical protein; [M] COG0773 UDP-N-acetylmuramate-alanine ligase. | [C] COG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.578 |
| EDZ46372.1 | hemD | RBY4I_1586 | RBY4I_2354 | Conserved hypothetical protein; [M] COG0773 UDP-N-acetylmuramate-alanine ligase. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.869 |
| EDZ46372.1 | tsaD | RBY4I_1586 | RBY4I_1082 | Conserved hypothetical protein; [M] COG0773 UDP-N-acetylmuramate-alanine ligase. | Peptidase M22, glycoprotease; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.590 |
| EDZ46409.1 | EDZ46372.1 | RBY4I_1623 | RBY4I_1586 | HemY domain protein; [H] COG3071 Uncharacterized enzyme of heme biosynthesis. | Conserved hypothetical protein; [M] COG0773 UDP-N-acetylmuramate-alanine ligase. | 0.886 |
| EDZ46409.1 | EDZ46805.1 | RBY4I_1623 | RBY4I_2022 | HemY domain protein; [H] COG3071 Uncharacterized enzyme of heme biosynthesis. | Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | 0.422 |
| EDZ46409.1 | EDZ48054.1 | RBY4I_1623 | RBY4I_3274 | HemY domain protein; [H] COG3071 Uncharacterized enzyme of heme biosynthesis. | [S] COG2350 Uncharacterized protein conserved in bacteria. | 0.588 |
| EDZ46409.1 | RBY4I_357 | RBY4I_1623 | RBY4I_357 | HemY domain protein; [H] COG3071 Uncharacterized enzyme of heme biosynthesis. | ubiquinol-Cytochrome c reductase, iron-sulfur subunit; [S] COG1673 Uncharacterized protein conserved in archaea. | 0.588 |
| EDZ46409.1 | gpsA | RBY4I_1623 | RBY4I_857 | HemY domain protein; [H] COG3071 Uncharacterized enzyme of heme biosynthesis. | [C] COG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.588 |
| EDZ46409.1 | hemD | RBY4I_1623 | RBY4I_2354 | HemY domain protein; [H] COG3071 Uncharacterized enzyme of heme biosynthesis. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.822 |
| EDZ46409.1 | tsaD | RBY4I_1623 | RBY4I_1082 | HemY domain protein; [H] COG3071 Uncharacterized enzyme of heme biosynthesis. | Peptidase M22, glycoprotease; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.588 |
| EDZ46805.1 | EDZ46372.1 | RBY4I_2022 | RBY4I_1586 | Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | Conserved hypothetical protein; [M] COG0773 UDP-N-acetylmuramate-alanine ligase. | 0.423 |
| EDZ46805.1 | EDZ46409.1 | RBY4I_2022 | RBY4I_1623 | Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | HemY domain protein; [H] COG3071 Uncharacterized enzyme of heme biosynthesis. | 0.422 |
| EDZ46805.1 | EDZ48054.1 | RBY4I_2022 | RBY4I_3274 | Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | [S] COG2350 Uncharacterized protein conserved in bacteria. | 0.694 |
| EDZ46805.1 | RBY4I_357 | RBY4I_2022 | RBY4I_357 | Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | ubiquinol-Cytochrome c reductase, iron-sulfur subunit; [S] COG1673 Uncharacterized protein conserved in archaea. | 0.695 |
| EDZ46805.1 | gpsA | RBY4I_2022 | RBY4I_857 | Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | [C] COG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.693 |
| EDZ46805.1 | hemD | RBY4I_2022 | RBY4I_2354 | Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.553 |