msrB protein (Rhodobacterales bacterium Y4I)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

msrB

methionine-R-sulfoxide reductase; [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase. (149 aa)

Predicted Functional Partners:

msrA_1

0.997

msrA_2

0.988

grpE

0.803

queC

0.727

rpoC

0.715

RBY4I_210

0.705

rpmJ

0.700

rplT

0.672

rpmG

0.659

rpsP

0.649

Your Current Organism:

Rhodobacterales bacterium Y4I

NCBI taxonomy Id: 439496
Other names: R. bacterium Y4I

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RBY4I_210	grpE	RBY4I_210	RBY4I_1751	60Kd inner membrane protein; [U] COG0706 Preprotein translocase subunit YidC.	Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]	0.527
RBY4I_210	msrA_1	RBY4I_210	RBY4I_3729	60Kd inner membrane protein; [U] COG0706 Preprotein translocase subunit YidC.	methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.572
RBY4I_210	msrA_2	RBY4I_210	RBY4I_2210	60Kd inner membrane protein; [U] COG0706 Preprotein translocase subunit YidC.	methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.572
RBY4I_210	msrB	RBY4I_210	RBY4I_681	60Kd inner membrane protein; [U] COG0706 Preprotein translocase subunit YidC.	methionine-R-sulfoxide reductase; [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase.	0.705
RBY4I_210	rplT	RBY4I_210	RBY4I_3899	60Kd inner membrane protein; [U] COG0706 Preprotein translocase subunit YidC.	Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.825
RBY4I_210	rpmG	RBY4I_210	RBY4I_991	60Kd inner membrane protein; [U] COG0706 Preprotein translocase subunit YidC.	[J] COG0267 Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family.	0.805
RBY4I_210	rpmJ	RBY4I_210	RBY4I_375	60Kd inner membrane protein; [U] COG0706 Preprotein translocase subunit YidC.	[J] COG0257 Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	0.726
RBY4I_210	rpoC	RBY4I_210	RBY4I_3474	60Kd inner membrane protein; [U] COG0706 Preprotein translocase subunit YidC.	DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.926
RBY4I_210	rpsP	RBY4I_210	RBY4I_1498	60Kd inner membrane protein; [U] COG0706 Preprotein translocase subunit YidC.	[J] COG0228 Ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family.	0.921
grpE	RBY4I_210	RBY4I_1751	RBY4I_210	Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]	60Kd inner membrane protein; [U] COG0706 Preprotein translocase subunit YidC.	0.527
grpE	msrB	RBY4I_1751	RBY4I_681	Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]	methionine-R-sulfoxide reductase; [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase.	0.803
grpE	rpoC	RBY4I_1751	RBY4I_3474	Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]	DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.504
msrA_1	RBY4I_210	RBY4I_3729	RBY4I_210	methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	60Kd inner membrane protein; [U] COG0706 Preprotein translocase subunit YidC.	0.572
msrA_1	msrB	RBY4I_3729	RBY4I_681	methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	methionine-R-sulfoxide reductase; [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase.	0.997
msrA_2	RBY4I_210	RBY4I_2210	RBY4I_210	methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	60Kd inner membrane protein; [U] COG0706 Preprotein translocase subunit YidC.	0.572
msrA_2	msrB	RBY4I_2210	RBY4I_681	methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	methionine-R-sulfoxide reductase; [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase.	0.988
msrB	RBY4I_210	RBY4I_681	RBY4I_210	methionine-R-sulfoxide reductase; [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase.	60Kd inner membrane protein; [U] COG0706 Preprotein translocase subunit YidC.	0.705
msrB	grpE	RBY4I_681	RBY4I_1751	methionine-R-sulfoxide reductase; [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase.	Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]	0.803
msrB	msrA_1	RBY4I_681	RBY4I_3729	methionine-R-sulfoxide reductase; [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase.	methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.997
msrB	msrA_2	RBY4I_681	RBY4I_2210	methionine-R-sulfoxide reductase; [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase.	methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.988