STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ltaEThreonine aldolase, low-specificity; [E] COG2008 Threonine aldolase. (344 aa)    
Predicted Functional Partners:
gcvP_1
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
 0.894
gcvP_2
[E] COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain.
    
 0.894
thrC
[E] COG0498 Threonine synthase.
  
 
 0.858
EDZ48113.1
Oxidoreductase, FAD/FMN-binding family; [O] COG0492 Thioredoxin reductase.
    
 0.796
RBY4I_938
[E] COG4583 Sarcosine oxidase gamma subunit.
  
  
  0.771
RBY4I_578
Sarcosine oxidase, delta subunit, heterotetrameric; [E] COG4311 Sarcosine oxidase delta subunit.
    
  0.756
EDZ46299.1
Oxidoreductase, FAD/FMN-binding family; [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases.
    
  0.732
RBY4I_247
[E] COG4583 Sarcosine oxidase gamma subunit.
     
  0.732
glyA_1
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.708
glyA_2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.708
Your Current Organism:
Rhodobacterales bacterium Y4I
NCBI taxonomy Id: 439496
Other names: R. bacterium Y4I
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