| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EDZ47179.1 | RBY4I_110 | RBY4I_2397 | RBY4I_110 | [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | Phenol hydroxylase component B; [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | 0.587 |
| EDZ47179.1 | ribB | RBY4I_2397 | RBY4I_533 | [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | Riboflavin biosynthesis protein ribAB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.434 |
| EDZ47179.1 | ribE | RBY4I_2397 | RBY4I_1943 | [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | [H] COG0307 Riboflavin synthase alpha chain. | 0.524 |
| EDZ47179.1 | ribF | RBY4I_2397 | RBY4I_753 | [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | Riboflavin biosynthesis protein RibF; [H] COG0196 FAD synthase; Belongs to the ribF family. | 0.739 |
| EDZ47280.1 | ribF | RBY4I_2498 | RBY4I_753 | [S] COG2983 Uncharacterized conserved protein; Belongs to the UPF0260 family. | Riboflavin biosynthesis protein RibF; [H] COG0196 FAD synthase; Belongs to the ribF family. | 0.758 |
| RBY4I_110 | EDZ47179.1 | RBY4I_110 | RBY4I_2397 | Phenol hydroxylase component B; [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | 0.587 |
| RBY4I_110 | ribB | RBY4I_110 | RBY4I_533 | Phenol hydroxylase component B; [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | Riboflavin biosynthesis protein ribAB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.434 |
| RBY4I_110 | ribE | RBY4I_110 | RBY4I_1943 | Phenol hydroxylase component B; [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | [H] COG0307 Riboflavin synthase alpha chain. | 0.400 |
| RBY4I_110 | ribF | RBY4I_110 | RBY4I_753 | Phenol hydroxylase component B; [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | Riboflavin biosynthesis protein RibF; [H] COG0196 FAD synthase; Belongs to the ribF family. | 0.752 |
| cmk | coaD | RBY4I_3717 | RBY4I_3668 | [F] COG0283 Cytidylate kinase. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.561 |
| cmk | ispDF | RBY4I_3717 | RBY4I_1505 | [F] COG0283 Cytidylate kinase. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); Belongs to the IspF family. In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.404 |
| cmk | ribF | RBY4I_3717 | RBY4I_753 | [F] COG0283 Cytidylate kinase. | Riboflavin biosynthesis protein RibF; [H] COG0196 FAD synthase; Belongs to the ribF family. | 0.918 |
| coaD | cmk | RBY4I_3668 | RBY4I_3717 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | [F] COG0283 Cytidylate kinase. | 0.561 |
| coaD | ispDF | RBY4I_3668 | RBY4I_1505 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); Belongs to the IspF family. In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.613 |
| coaD | ribB | RBY4I_3668 | RBY4I_533 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Riboflavin biosynthesis protein ribAB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.635 |
| coaD | ribD | RBY4I_3668 | RBY4I_3963 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.525 |
| coaD | ribF | RBY4I_3668 | RBY4I_753 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Riboflavin biosynthesis protein RibF; [H] COG0196 FAD synthase; Belongs to the ribF family. | 0.748 |
| ispDF | cmk | RBY4I_1505 | RBY4I_3717 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); Belongs to the IspF family. In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | [F] COG0283 Cytidylate kinase. | 0.404 |
| ispDF | coaD | RBY4I_1505 | RBY4I_3668 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); Belongs to the IspF family. In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.613 |
| ispDF | ribD | RBY4I_1505 | RBY4I_3963 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); Belongs to the IspF family. In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.579 |