| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cobB | cobF | RBY4I_2910 | RBY4I_1803 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | 0.848 |
| cobB | cobG | RBY4I_2910 | RBY4I_405 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-3B synthase; [P] COG0155 Sulfite reductase, beta subunit (hemoprotein). | 0.692 |
| cobB | cobH | RBY4I_2910 | RBY4I_780 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-8X methylmutase; [H] COG2082 Precorrin isomerase. | 0.993 |
| cobB | cobI | RBY4I_2910 | RBY4I_3879 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | [H] COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family. | 0.897 |
| cobB | cobJ | RBY4I_2910 | RBY4I_267 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-3B C17-methyltransferase; [H] COG0007 Uroporphyrinogen-III methylase. | 0.899 |
| cobB | cobK | RBY4I_2910 | RBY4I_1269 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | [H] COG2099 Precorrin-6x reductase. | 0.923 |
| cobB | cobM | RBY4I_2910 | RBY4I_3972 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-4 C11-methyltransferase; [H] COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family. | 0.982 |
| cobB | cobN | RBY4I_2910 | RBY4I_2923 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobaltochelatase, CobN subunit; [H] COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. | 0.983 |
| cobB | cobQ | RBY4I_2910 | RBY4I_2778 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.988 |
| cobB | cobl | RBY4I_2910 | RBY4I_3532 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-6Y C(5,15)-methyltransferase (decarboxylating); [H] COG2242 Precorrin-6B methylase 2. | 0.945 |
| cobF | cobB | RBY4I_1803 | RBY4I_2910 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.848 |
| cobF | cobG | RBY4I_1803 | RBY4I_405 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | precorrin-3B synthase; [P] COG0155 Sulfite reductase, beta subunit (hemoprotein). | 0.865 |
| cobF | cobH | RBY4I_1803 | RBY4I_780 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | precorrin-8X methylmutase; [H] COG2082 Precorrin isomerase. | 0.986 |
| cobF | cobI | RBY4I_1803 | RBY4I_3879 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | [H] COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family. | 0.883 |
| cobF | cobJ | RBY4I_1803 | RBY4I_267 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | precorrin-3B C17-methyltransferase; [H] COG0007 Uroporphyrinogen-III methylase. | 0.984 |
| cobF | cobK | RBY4I_1803 | RBY4I_1269 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | [H] COG2099 Precorrin-6x reductase. | 0.993 |
| cobF | cobM | RBY4I_1803 | RBY4I_3972 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | Precorrin-4 C11-methyltransferase; [H] COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family. | 0.995 |
| cobF | cobN | RBY4I_1803 | RBY4I_2923 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | Cobaltochelatase, CobN subunit; [H] COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. | 0.817 |
| cobF | cobQ | RBY4I_1803 | RBY4I_2778 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.865 |
| cobF | cobl | RBY4I_1803 | RBY4I_3532 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | precorrin-6Y C(5,15)-methyltransferase (decarboxylating); [H] COG2242 Precorrin-6B methylase 2. | 0.988 |