hrcA protein (Crocosphaera subtropica) - STRING interaction network

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hrcA

Heat-inducible transcriptional repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (369 aa)

Predicted Functional Partners:

grpE

0.936

ntcB

0.743

ntcA

0.714

dnaK1

0.699

dnaK3

0.698

dnaK2

0.697

cce_1389

0.693

groEL1

0.675

groEL2

0.675

rpaB

0.628

Your Current Organism:

Crocosphaera subtropica

NCBI taxonomy Id: 43989
Other names: C. subtropica ATCC 51142, Crocosphaera subtropica ATCC 51142, Cyanothece sp. ATCC 51142, Cyanothece sp. BH68, Cyanothece sp. BH68K

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cce_1389	hrcA	cce_1389	cce_1388	Unknown; Contains a Rhodanese-like domain.	Heat-inducible transcriptional repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.693
dnaK1	dnaK2	cce_2003	cce_4004	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.904
dnaK1	dnaK3	cce_2003	cce_1356	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.902
dnaK1	groEL1	cce_2003	cce_1344	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperonin 1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.966
dnaK1	groEL2	cce_2003	cce_3330	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperonin 2; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.966
dnaK1	grpE	cce_2003	cce_4005	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...]	0.994
dnaK1	hrcA	cce_2003	cce_1388	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat-inducible transcriptional repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.699
dnaK2	dnaK1	cce_4004	cce_2003	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.904
dnaK2	dnaK3	cce_4004	cce_1356	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.908
dnaK2	groEL1	cce_4004	cce_1344	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperonin 1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.966
dnaK2	groEL2	cce_4004	cce_3330	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperonin 2; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.967
dnaK2	grpE	cce_4004	cce_4005	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...]	0.997
dnaK2	hrcA	cce_4004	cce_1388	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat-inducible transcriptional repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.697
dnaK3	dnaK1	cce_1356	cce_2003	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.902
dnaK3	dnaK2	cce_1356	cce_4004	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.908
dnaK3	groEL1	cce_1356	cce_1344	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperonin 1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.966
dnaK3	groEL2	cce_1356	cce_3330	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperonin 2; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.966
dnaK3	grpE	cce_1356	cce_4005	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...]	0.993
dnaK3	hrcA	cce_1356	cce_1388	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat-inducible transcriptional repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.698
groEL1	dnaK1	cce_1344	cce_2003	Chaperonin 1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.966

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