Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cobAuroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (267 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.982
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.972
hemD
Bifunctional uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; Belongs to the precorrin methyltransferase family.
 
 
0.935
cbiL
Precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family.
 
  
 0.933
cce_4308
Hypothetical protein; Contains a cobalamin (vitamin B12) biosynthesis CbiX domain.
  
 0.912
nirA
Ferredoxin-nitrite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.907
cysH
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.870
sir
Ferredoxin-sulfite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.853
cce_3701
Hypothetical protein; Contains a cobalamin (vitamin B12) biosynthesis CbiX domain.
  
  
 0.839
cbiGH
Probable bifunctional Cobalamin (vitamin B12) biosynthesis/precorrin-3B C17-methyltransferase.
  
0.713
Your Current Organism:
Crocosphaera subtropica
NCBI taxonomy Id: 43989
Other names: C. subtropica ATCC 51142, Crocosphaera subtropica ATCC 51142, Cyanothece sp. ATCC 51142, Cyanothece sp. BH68, Cyanothece sp. BH68K
Server load: medium (58%) [HD]