purA protein (Crocosphaera subtropica) - STRING interaction network

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purA

Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (446 aa)

Predicted Functional Partners:

purB

0.998

guaB

0.987

purH

0.987

purC

0.977

purE

0.973

purK

0.959

cce_1776

0.952

guaA

0.949

purN

0.947

argG

0.935

Your Current Organism:

Crocosphaera subtropica

NCBI taxonomy Id: 43989
Other names: C. subtropica ATCC 51142, Crocosphaera subtropica ATCC 51142, Cyanothece sp. ATCC 51142, Cyanothece sp. BH68, Cyanothece sp. BH68K

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
argG	purA	cce_4370	cce_4221	Argininosuccinate synthetase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.935
cce_1776	guaA	cce_1776	cce_3266	Putative Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.970
cce_1776	guaB	cce_1776	cce_3209	Putative Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	IMP dehydrogenase.	0.942
cce_1776	purA	cce_1776	cce_4221	Putative Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.952
cce_1776	purE	cce_1776	cce_4638	Putative Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.460
cce_1776	purH	cce_1776	cce_4354	Putative Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Bifunctional purine biosynthesis protein, phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.	0.930
guaA	cce_1776	cce_3266	cce_1776	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Putative Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.970
guaA	guaB	cce_3266	cce_3209	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	IMP dehydrogenase.	0.999
guaA	purA	cce_3266	cce_4221	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.949
guaA	purB	cce_3266	cce_3816	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.945
guaA	purC	cce_3266	cce_2380	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.	0.746
guaA	purE	cce_3266	cce_4638	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.694
guaA	purH	cce_3266	cce_4354	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Bifunctional purine biosynthesis protein, phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.	0.949
guaA	purK	cce_3266	cce_1273	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).	0.738
guaA	purN	cce_3266	cce_0426	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.	0.702
guaB	cce_1776	cce_3209	cce_1776	IMP dehydrogenase.	Putative Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.942
guaB	guaA	cce_3209	cce_3266	IMP dehydrogenase.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.999
guaB	purA	cce_3209	cce_4221	IMP dehydrogenase.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.987
guaB	purB	cce_3209	cce_3816	IMP dehydrogenase.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.849
guaB	purC	cce_3209	cce_2380	IMP dehydrogenase.	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.	0.544

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