STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (331 aa)    
Predicted Functional Partners:
hemD
Bifunctional uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; Belongs to the precorrin methyltransferase family.
 0.999
hemA
Transfer RNA-Gln reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.998
hemB3
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.993
hemB2
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.993
hemB1
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.993
hemL
Glutamate-1-semialdehyde aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
  
 0.984
cobA
uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
  
 0.983
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.969
chlD
Magnesium chelatase, ATPase subunit D; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.
  
  
 0.905
cbiJ
Probable precorrin-6x reductase.
    
 0.840
Your Current Organism:
Crocosphaera subtropica
NCBI taxonomy Id: 43989
Other names: C. subtropica ATCC 51142, Crocosphaera subtropica ATCC 51142, Cyanothece sp. ATCC 51142, Cyanothece sp. BH68, Cyanothece sp. BH68K
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