STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rskAAnti-sigma factor; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regula [...] (232 aa)    
Predicted Functional Partners:
ORV35409.1
RNA polymerase subunit sigma; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily.
 
   
 0.954
ORV35408.1
Thiol:disulfide interchange protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.693
ORV35483.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.499
ORV37551.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.474
ORV41930.1
MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.456
ORV41919.1
Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.453
ORV39893.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.445
ORV42396.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.432
ORV37636.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.421
ORV47110.1
Zn-dependent protease with chaperone function; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.404
Your Current Organism:
Mycobacterium conspicuum
NCBI taxonomy Id: 44010
Other names: ATCC 700090, CIP 105165, DSM 44136, JCM 14738, M. conspicuum, strain 3895/92
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.