CUH81719.1 protein (Tropicibacter naphthalenivorans)

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

CUH81719.1

Hypothetical protein. (108 aa)

Predicted Functional Partners:

CUH81715.1

0.881

virB4

0.875

CUH81713.1

0.875

CUH81706.1

0.862

CUH81704.1

0.861

ptlG

0.859

CUH81695.1

0.857

virB9

0.856

slt_4

0.844

CUH81698.1

0.791

Your Current Organism:

Tropicibacter naphthalenivorans

NCBI taxonomy Id: 441103
Other names: DSM 19561, JCM 14838, T. naphthalenivorans, Tropicibacter naphthalenivorans Harwati et al. 2009, alpha proteobacterium C02, strain C02

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUH81695.1	CUH81698.1	TRN7648_03591	TRN7648_03593	TrbL/VirB6 plasmid conjugal transfer protein.	Type IV secretion system protein VirB11.	0.939
CUH81695.1	CUH81704.1	TRN7648_03591	TRN7648_03596	TrbL/VirB6 plasmid conjugal transfer protein.	Type IV secretion system protein VirB8.	0.995
CUH81695.1	CUH81706.1	TRN7648_03591	TRN7648_03597	TrbL/VirB6 plasmid conjugal transfer protein.	P-type DNA transfer protein VirB5.	0.962
CUH81695.1	CUH81713.1	TRN7648_03591	TRN7648_03601	TrbL/VirB6 plasmid conjugal transfer protein.	Type IV secretion system protein VirB3.	0.994
CUH81695.1	CUH81715.1	TRN7648_03591	TRN7648_03602	TrbL/VirB6 plasmid conjugal transfer protein.	Type IV secretory pathway, VirB2 components (pilins).	0.954
CUH81695.1	CUH81719.1	TRN7648_03591	TRN7648_03604	TrbL/VirB6 plasmid conjugal transfer protein.	Hypothetical protein.	0.857
CUH81695.1	ptlG	TRN7648_03591	TRN7648_03594	TrbL/VirB6 plasmid conjugal transfer protein.	Pertussis toxin liberation protein G.	0.996
CUH81695.1	slt_4	TRN7648_03591	TRN7648_03598	TrbL/VirB6 plasmid conjugal transfer protein.	Soluble lytic murein transglycosylase precursor.	0.944
CUH81695.1	virB4	TRN7648_03591	TRN7648_03600	TrbL/VirB6 plasmid conjugal transfer protein.	Type IV secretion system protein virB4.	0.996
CUH81695.1	virB9	TRN7648_03591	TRN7648_03595	TrbL/VirB6 plasmid conjugal transfer protein.	Type IV secretion system protein virB9 precursor.	0.996
CUH81698.1	CUH81695.1	TRN7648_03593	TRN7648_03591	Type IV secretion system protein VirB11.	TrbL/VirB6 plasmid conjugal transfer protein.	0.939
CUH81698.1	CUH81704.1	TRN7648_03593	TRN7648_03596	Type IV secretion system protein VirB11.	Type IV secretion system protein VirB8.	0.949
CUH81698.1	CUH81706.1	TRN7648_03593	TRN7648_03597	Type IV secretion system protein VirB11.	P-type DNA transfer protein VirB5.	0.945
CUH81698.1	CUH81713.1	TRN7648_03593	TRN7648_03601	Type IV secretion system protein VirB11.	Type IV secretion system protein VirB3.	0.948
CUH81698.1	CUH81715.1	TRN7648_03593	TRN7648_03602	Type IV secretion system protein VirB11.	Type IV secretory pathway, VirB2 components (pilins).	0.964
CUH81698.1	CUH81719.1	TRN7648_03593	TRN7648_03604	Type IV secretion system protein VirB11.	Hypothetical protein.	0.791
CUH81698.1	ptlG	TRN7648_03593	TRN7648_03594	Type IV secretion system protein VirB11.	Pertussis toxin liberation protein G.	0.987
CUH81698.1	slt_4	TRN7648_03593	TRN7648_03598	Type IV secretion system protein VirB11.	Soluble lytic murein transglycosylase precursor.	0.947
CUH81698.1	virB4	TRN7648_03593	TRN7648_03600	Type IV secretion system protein VirB11.	Type IV secretion system protein virB4.	0.990
CUH81698.1	virB9	TRN7648_03593	TRN7648_03595	Type IV secretion system protein VirB11.	Type IV secretion system protein virB9 precursor.	0.991

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

96

PPI enrichment p-value:

0.692

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

4 of 44

1.68

1.39

0.0010

GO:0006631

Fatty acid metabolic process

5 of 86

1.49

1.34

0.00057

GO:0044249

Cellular biosynthetic process

8 of 908

0.67

0.45

0.0120

GO:1901576

Organic substance biosynthetic process

8 of 950

0.65

0.44

0.0120

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

4 of 19

2.05

2.11

5.52e-05

GO:0004314

[Acyl-carrier-protein] S-malonyltransferase activity

2 of 2

2.72

1.14

0.0085

GO:0031177

Phosphopantetheine binding

2 of 5

2.32

1.07

0.0104

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

2 of 14

1.88

0.76

0.0352

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:451

Phosphopantetheine, and Condensation domain

8 of 21

2.3

6.37

9.28e-15

CL:454

Phosphopantetheine, and Siderophore metabolic process

7 of 14

2.42

6.17

1.56e-13

CL:456

Phosphopantetheine attachment site

6 of 7

2.65

6.03

1.88e-12

CL:434

Mixed, incl. Fatty acid biosynthetic process, and AMP-binding enzyme

11 of 99

1.77

4.72

8.59e-17

CL:435

Mixed, incl. AMP-binding enzyme, and Alpha/beta hydrolase fold-1

9 of 68

1.84

4.5

1.07e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01053

Biosynthesis of siderophore group nonribosomal peptides

2 of 7

2.18

0.96

0.0160

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

6 of 18

2.24

4.52

2.85e-10

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

6 of 16

2.3

4.48

5.49e-10

PF00668

Condensation domain

4 of 10

2.32

2.84

2.96e-06

PF00698

Acyl transferase domain

3 of 3

2.72

2.46

2.88e-05

PF00501

AMP-binding enzyme

4 of 26

1.91

2.08

3.99e-05

PF13193

AMP-binding enzyme C-terminal domain

3 of 16

1.99

1.56

0.00083

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

6 of 18

2.24

4.14

2.50e-09

IPR009081

Phosphopantetheine binding ACP domain

6 of 18

2.24

4.14

2.50e-09

IPR020806

Polyketide synthase, phosphopantetheine-binding domain

5 of 11

2.38

3.83

2.63e-08

IPR001242

Condensation domain

4 of 10

2.32

2.79

3.74e-06

IPR006162

Phosphopantetheine attachment site

4 of 12

2.24

2.68

5.43e-06

(more ...)

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