node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFB70432.1 | SFB76141.1 | SAMN04488094_10121 | SAMN04488094_101349 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.998 |
SFB70432.1 | SFB78256.1 | SAMN04488094_10121 | SAMN04488094_101471 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.905 |
SFB70432.1 | SFC95978.1 | SAMN04488094_10121 | SAMN04488094_11231 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Aminomethyltransferase. | 0.826 |
SFB70432.1 | fhs | SAMN04488094_10121 | SAMN04488094_101799 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.915 |
SFB70432.1 | folD | SAMN04488094_10121 | SAMN04488094_11260 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.802 |
SFB70432.1 | glyA | SAMN04488094_10121 | SAMN04488094_12229 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.833 |
SFB70432.1 | purN | SAMN04488094_10121 | SAMN04488094_10111 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.827 |
SFB70432.1 | purU | SAMN04488094_10121 | SAMN04488094_108100 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.845 |
SFB76141.1 | SFB70432.1 | SAMN04488094_101349 | SAMN04488094_10121 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.998 |
SFB76141.1 | SFB78256.1 | SAMN04488094_101349 | SAMN04488094_101471 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.906 |
SFB76141.1 | SFC95978.1 | SAMN04488094_101349 | SAMN04488094_11231 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Aminomethyltransferase. | 0.814 |
SFB76141.1 | fhs | SAMN04488094_101349 | SAMN04488094_101799 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.844 |
SFB76141.1 | glyA | SAMN04488094_101349 | SAMN04488094_12229 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.833 |
SFB76141.1 | purU | SAMN04488094_101349 | SAMN04488094_108100 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.804 |
SFB78256.1 | SFB70432.1 | SAMN04488094_101471 | SAMN04488094_10121 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.905 |
SFB78256.1 | SFB76141.1 | SAMN04488094_101471 | SAMN04488094_101349 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.906 |
SFB78256.1 | SFC95978.1 | SAMN04488094_101471 | SAMN04488094_11231 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase. | 0.904 |
SFB78256.1 | fhs | SAMN04488094_101471 | SAMN04488094_101799 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.952 |
SFB78256.1 | folD | SAMN04488094_101471 | SAMN04488094_11260 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.775 |
SFB78256.1 | glyA | SAMN04488094_101471 | SAMN04488094_12229 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.879 |