SFP34660.1 protein (Tranquillimonas alkanivorans)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

SFP34660.1

Urease accessory protein. (214 aa)

Predicted Functional Partners:

SFP17398.1

0.662

SFP34624.1

0.598

SFP34595.1

0.565

ureB

0.540

SFP34560.1

0.535

SFQ03789.1

0.535

ureG

0.475

ureC

0.418

ureE

0.408

Your Current Organism:

Tranquillimonas alkanivorans

NCBI taxonomy Id: 441119
Other names: DSM 19547, JCM 14836, T. alkanivorans, Tranquillimonas alkanivorans Harwati et al. 2008, alpha proteobacterium A34, strain A34

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFP17398.1	SFP34660.1	SAMN04488047_103123	SAMN04488047_105150	Rho termination factor, N-terminal domain.	Urease accessory protein.	0.662
SFP17398.1	SFQ03789.1	SAMN04488047_103123	SAMN04488047_12819	Rho termination factor, N-terminal domain.	SIS domain-containing protein.	0.455
SFP34560.1	SFP34595.1	SAMN04488047_105147	SAMN04488047_105148	Cobaltochelatase CobN subunit.	Putative acetyltransferase.	0.675
SFP34560.1	SFP34624.1	SAMN04488047_105147	SAMN04488047_105149	Cobaltochelatase CobN subunit.	Cobalamin biosynthesis protein CobW.	0.961
SFP34560.1	SFP34660.1	SAMN04488047_105147	SAMN04488047_105150	Cobaltochelatase CobN subunit.	Urease accessory protein.	0.535
SFP34595.1	SFP34560.1	SAMN04488047_105148	SAMN04488047_105147	Putative acetyltransferase.	Cobaltochelatase CobN subunit.	0.675
SFP34595.1	SFP34624.1	SAMN04488047_105148	SAMN04488047_105149	Putative acetyltransferase.	Cobalamin biosynthesis protein CobW.	0.776
SFP34595.1	SFP34660.1	SAMN04488047_105148	SAMN04488047_105150	Putative acetyltransferase.	Urease accessory protein.	0.565
SFP34624.1	SFP34560.1	SAMN04488047_105149	SAMN04488047_105147	Cobalamin biosynthesis protein CobW.	Cobaltochelatase CobN subunit.	0.961
SFP34624.1	SFP34595.1	SAMN04488047_105149	SAMN04488047_105148	Cobalamin biosynthesis protein CobW.	Putative acetyltransferase.	0.776
SFP34624.1	SFP34660.1	SAMN04488047_105149	SAMN04488047_105150	Cobalamin biosynthesis protein CobW.	Urease accessory protein.	0.598
SFP34624.1	ureG	SAMN04488047_105149	SAMN04488047_10816	Cobalamin biosynthesis protein CobW.	Urease accessory protein; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.	0.477
SFP34660.1	SFP17398.1	SAMN04488047_105150	SAMN04488047_103123	Urease accessory protein.	Rho termination factor, N-terminal domain.	0.662
SFP34660.1	SFP34560.1	SAMN04488047_105150	SAMN04488047_105147	Urease accessory protein.	Cobaltochelatase CobN subunit.	0.535
SFP34660.1	SFP34595.1	SAMN04488047_105150	SAMN04488047_105148	Urease accessory protein.	Putative acetyltransferase.	0.565
SFP34660.1	SFP34624.1	SAMN04488047_105150	SAMN04488047_105149	Urease accessory protein.	Cobalamin biosynthesis protein CobW.	0.598
SFP34660.1	SFQ03789.1	SAMN04488047_105150	SAMN04488047_12819	Urease accessory protein.	SIS domain-containing protein.	0.535
SFP34660.1	ureB	SAMN04488047_105150	SAMN04488047_10823	Urease accessory protein.	Urease subunit beta; Belongs to the urease beta subunit family.	0.540
SFP34660.1	ureC	SAMN04488047_105150	SAMN04488047_10820	Urease accessory protein.	Urease subunit alpha.	0.418
SFP34660.1	ureE	SAMN04488047_105150	SAMN04488047_10818	Urease accessory protein.	Urease accessory protein; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.	0.408

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.828

expected number of edges:

11

PPI enrichment p-value:

3.05e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

11 of 641

0.85

0.89

7.45e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015099

Nickel cation transmembrane transporter activity

10 of 36

2.06

6.23

3.69e-17

GO:0015413

ABC-type nickel transporter activity

2 of 2

2.61

1.41

0.0026

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

11 of 895

0.7

0.67

2.86e-06

GO:0016021

Integral component of membrane

9 of 1090

0.53

0.41

0.0035

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6402

Nickel cation transmembrane transporter activity, and Peptide transport

10 of 47

1.94

5.58

1.01e-16

CL:6399

Nickel cation transmembrane transporter activity, and Peptide transport

11 of 65

1.84

5.23

1.49e-17

CL:6485

ABC-type nickel transporter activity, and Oligopeptide transport permease C-like, N-terminal domain

5 of 5

2.61

4.76

6.98e-10

CL:6403

Nickel cation transmembrane transporter activity, and Peptide transport

5 of 41

1.7

2.25

3.34e-06

CL:6404

Nickel cation transmembrane transporter activity, and Peptide transport

3 of 30

1.61

1.1

0.0045

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

siw02024

Quorum sensing

5 of 160

1.11

0.87

0.0026

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

9 of 90

1.61

3.41

1.15e-12

MAP-9635486

Infection with Mycobacterium tuberculosis

9 of 151

1.39

2.41

4.87e-11

MAP-5663205

Infectious disease

9 of 154

1.38

2.39

4.87e-11

MAP-1643685

Disease

9 of 158

1.37

2.35

4.87e-11

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

6 of 64

1.58

2.17

1.50e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0813

Transport

9 of 317

1.07

1.27

5.15e-07

KW-1003

Cell membrane

9 of 322

1.06

1.25

5.15e-07

KW-1133

Transmembrane helix

8 of 948

0.54

0.36

0.0195

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12911

N-terminal TM domain of oligopeptide transport permease C

5 of 11

2.27

3.65

3.98e-08

PF00528

Binding-protein-dependent transport system inner membrane component

8 of 96

1.53

2.57

5.85e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR025966

Oligopeptide transport permease C-like, N-terminal domain

6 of 11

2.35

4.49

7.69e-10

IPR035906

MetI-like superfamily

8 of 97

1.53

2.53

8.11e-09

IPR000515

ABC transporter type 1, transmembrane domain MetI-like

8 of 97

1.53

2.53

8.11e-09

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