node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACL_0688 | argE | ACL_0688 | ACL_0692 | Hypothetical protein. | Acetylornithine deacetylase. | 0.745 |
ACL_0688 | folA | ACL_0688 | ACL_0690 | Hypothetical protein. | Dihydrofolate reductase. | 0.785 |
ACL_0688 | plsC | ACL_0688 | ACL_0689 | Hypothetical protein. | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | 0.785 |
ACL_0688 | thyA | ACL_0688 | ACL_0691 | Hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.785 |
argE | ACL_0688 | ACL_0692 | ACL_0688 | Acetylornithine deacetylase. | Hypothetical protein. | 0.745 |
argE | folA | ACL_0692 | ACL_0690 | Acetylornithine deacetylase. | Dihydrofolate reductase. | 0.812 |
argE | plsC | ACL_0692 | ACL_0689 | Acetylornithine deacetylase. | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | 0.751 |
argE | thyA | ACL_0692 | ACL_0691 | Acetylornithine deacetylase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.752 |
fhs | folA | ACL_0032 | ACL_0690 | Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase. | 0.928 |
fhs | folC | ACL_0032 | ACL_0542 | Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.655 |
fhs | gcvH | ACL_0032 | ACL_0397 | Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system, H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.401 |
fhs | gcvT | ACL_0032 | ACL_0398 | Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system, T protein; Aminomethyltransferase. | 0.942 |
fhs | glyA | ACL_0032 | ACL_0047 | Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.964 |
fmt | folA | ACL_0325 | ACL_0690 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Dihydrofolate reductase. | 0.927 |
fmt | gcvT | ACL_0325 | ACL_0398 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine cleavage system, T protein; Aminomethyltransferase. | 0.924 |
fmt | glyA | ACL_0325 | ACL_0047 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.920 |
fmt | thyA | ACL_0325 | ACL_0691 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.512 |
folA | ACL_0688 | ACL_0690 | ACL_0688 | Dihydrofolate reductase. | Hypothetical protein. | 0.785 |
folA | argE | ACL_0690 | ACL_0692 | Dihydrofolate reductase. | Acetylornithine deacetylase. | 0.812 |
folA | fhs | ACL_0690 | ACL_0032 | Dihydrofolate reductase. | Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. | 0.928 |