STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MANSC4MANSC domain-containing protein 4. (346 aa)    
Predicted Functional Partners:
CAP1
Cyclase associated actin cytoskeleton regulatory protein 1.
   
 
 0.687
CAP2
Adenylyl cyclase-associated protein; Belongs to the CAP family.
   
 
 0.687
GAK
Cyclin-G-associated kinase.
   
 
 0.663
CAPZB
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
   
 0.644
ACTR2
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
   
 
 0.615
HIP1
Huntingtin interacting protein 1.
    
 
 0.591
WASL
Neural Wiskott-Aldrich syndrome protein.
    
 
 0.571
LRIT1
Leucine rich repeat, Ig-like and transmembrane domains 1.
    
 
 0.545
BIN1
Myc box-dependent-interacting protein 1.
   
 
 0.544
AMPH
Amphiphysin.
   
 
 0.544
Your Current Organism:
Struthio camelus
NCBI taxonomy Id: 441894
Other names: S. camelus australis, Struthio camelus australis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.