STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tropHAldehyde dehydrogenase tropH; Aldehyde dehydrogenase; part of the gene cluster that mediates the biosynthesis of the tropolone class of fungal maleic anhydrides. The pathway begins with the synthesis of 3-methylorcinaldehyde by the non-reducing polyketide synthase (PKS) tropA. 3-methylorcinaldehyde is the substrate for the FAD-dependent monooxygenase tropB to yield a dearomatized hydroxycyclohexadione. The 2-oxoglutarate-dependent dioxygenase tropC then performs the oxidative ring expansion to provide the first tropolone metabolite stipitaldehyde. Trop D converts stipitaldehyde into st [...] (515 aa)    
Predicted Functional Partners:
TSTA_081290
Pyruvate decarboxylase, putative.
   
 0.884
TSTA_077630
Acetyl-coenzyme A synthetase.
   
 0.848
TSTA_090470
Acyl-CoA synthetase, putative.
   
 0.848
TSTA_078790
Methylmalonate-semialdehyde dehydrogenase, putative.
  
 
0.847
TSTA_119660
4-aminobutyrate transaminase GatA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
   
 0.845
TSTA_020360
3-hydroxyisobutyrate dehydrogenase.
   
  0.824
TSTA_070970
Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.820
TSTA_083490
Glutamate decarboxylase; Belongs to the group II decarboxylase family.
   
  0.820
TSTA_069950
NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.817
TSTA_030340
S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
   
 0.814
Your Current Organism:
Talaromyces stipitatus
NCBI taxonomy Id: 441959
Other names: T. stipitatus ATCC 10500, Talaromyces stipitatus ATCC 10500
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.